| Gene Symbol | CSNK1G2 |
|---|---|
| Entrez Gene | 1455 |
| Alt Symbol | CK1g2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 1, gamma 2 |
| Other Description | CKI-gamma 2|casein kinase 1 isoform gamma-2|casein kinase I isoform gamma-2 |
| Swissprots | P78368 Q8WUB1 O00704 B5BU42 |
| Accessions | AAC26983 EAW69426 EAW69427 EAW69428 EAW69429 EAW69430 EAW69431 P78368 AB451278 BAG70092 AB451410 BAG70224 AF001177 AAC00212 AY007134 AAG01997 BC018693 AAH18693 BC018699 AAH18699 BC020972 AAH20972 BT009922 AAP88924 CA423327 CR994929 DQ890695 ABM81621 DQ893880 ABM84806 U89896 AAB88627 XM_005259498 XP_005259555 XM_005259499 XP_005259556 XM_005259500 XP_005259557 XM_005259501 XP_005259558 XR_430129 NM_001319 NP_001310 |
| Function | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15342122, ECO:0000269|PubMed:15917222, ECO:000 |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15077195}. |
| Tissue Specificity | Testis. |
| Top Pathways | Hedgehog signaling pathway |