| Gene Symbol |
Trpc4
|
| Entrez Gene |
22066
|
| Alt Symbol |
CCE1, STRPC4, Trp4, Trrp4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily C, member 4
|
| Other Description |
capacitative calcium entry channel Trp4|putative capacitative calcium entry channel|receptor-activated cation channel TRP4|short transient receptor potential channel 4|transient receptor protein 4
|
| Swissprots |
Q62350 Q9QUQ9 Q9QUQ5 Q9QZC0
|
| Accessions |
EDL35253 EDL35254 EDL35255 EDL35256 Q9QUQ5 AF011543 AAD10167 AF019663 AAD10168 AF190646 AAF01469 AK044265 AK049788 AK080670 BAC37973 AK084109 AK084139 BAC39124 BC057335 BC060160 BC120729 AAI20730 BC131915 AAI31916 CO043592 U50921 AAC05178 U50922 AAC05179 X90697 CAA62230 XM_006501296 XP_006501359 XM_006501297 XP_006501360 XM_006501298 XP_006501361 NM_001253682 NP_001240611 NM_001253683 NP_001240612 NM_016984 NP_058680 NR_046161
|
| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell- cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells. {ECO:0000250, ECO:0000269|PubMed:11175743}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.
|