ATL1

Gene Symbol ATL1
Entrez Gene 51062
Alt Symbol AD-FSP, FSP1, GBP3, HSN1D, SPG3, SPG3A, atlastin1
Species Human
Gene Type protein-coding
Description atlastin GTPase 1
Other Description GBP-3|GTP-binding protein 3|atlastin-1|brain-specific GTP-binding protein|guanine nucleotide-binding protein 3|guanylate-binding protein 3|hGBP3|spastic paraplegia 3 protein A
Swissprots A6NND5 O95890 Q8WXF7 Q69YH7 Q96FK0 A8K2C0 G5E9T1
Accessions CAH25961 EAW65705 EAW65706 EAW65707 EAW65708 EAW65709 Q8WXF7 AF131801 AAD20047 AF444143 AAL37898 AK223436 BAD97156 AK290185 BAF82874 AK312518 AL833591 CAH10392 AW674605 AY032844 AAK51160 BC010708 AAH10708 BG704589 BI601372 CR457153 CAG33434 DA088230 DA397302 R61338 NM_001127713 NP_001121185 NM_015915 NP_056999 NM_181598 NP_853629
Function GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:23334294}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250}.
Tissue Specificity Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207}.

Atlastin-1 (D2E6) Rabbit mAb - 12728 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E6
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human atlastin-1 (hAlastin-1-Myc/DDK; +), atlastin-2 (hAlastin-2-Myc/DDK; +) or atlastin-3 (hAlastin-3-Myc/DDK; +) protein, using Atlastin-1 (D2E6) Rabbit mAb (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower).

Atlastin (B-12) - sc-374175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Atlastin (B-12): sc-374175. Western blot analysis of Atlastin expression in non-transfected: sc-110760 (A) and human Atlastin transfected: sc-111145 (B) 293 whole cell lysates.

Atlastin (E-9) - sc-376619 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Atlastin (E-9): sc-376619. Western blot analysis of Atlastin expression in non-transfected: sc-110760 (A) and human Atlastin transfected: sc-111145 (B) 293 whole cell lysates.

Atlastin (H-37) - sc-67232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Atlastin (H-37): sc-67232. Western blot analysis of Atlastin expression in human platelet extract (A) and mouse brain tissue extract (B).

Atlastin (M-17) - sc-49158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atlastin (M-17): sc-49158. Western blot analysis of Atlastin expression in non-transfected: sc-110760 (A) and human Atlastin transfected: sc-111145 (B) 293 whole cell lysates.

Atlastin (C-16) - sc-49157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atlastin (C-16): sc-49157. Western blot analysis of Atlastin expression in non-transfected: sc-110760 (A) and human Atlastin transfected: sc-111145 (B) 293 whole cell lysates.

Anti-SPG3A antibody - ab58273 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab58273 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal Goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab58273, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 Goat anti-Mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SPG3A antibody - ab196573 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of A549 cells labeling SPG3A with ab196573 at a 1/50 dilution.

Anti-SPG3A antibody - ab130348 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SPG3A antibody (ab130348) at 1/100 dilution + NCI-H292 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-ATL1 Antibody (aa476-504, APC) - LS-C232967 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504, Biotin) - LS-C232968 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504, AP) - LS-C232966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504, FITC) - LS-C232969 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504, PE) - LS-C232970 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504, Azide-free, HRP) - LS-C249484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (aa476-504) - LS-C319671 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody - LS-C341568 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-ATL1 Antibody (C-Terminus) - LS-C187334 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Brain. SPG3A antibody dilution 1.0 ug/ml.

Anti-ATL1 Antibody (clone 1B11) - LS-C139454 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B11
SPG3A monoclonal antibody (M10), clone 1B11. Western blot of SPG3A expression in IMR-32.

Anti-ATL1 Antibody (aa476-504) - LS-C156629 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ATL1 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The ATL1 antibody detected the ATL1 protein (arrow).

Anti-ATL1 Antibody - LS-C333967 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using ATL1 antibody. Blue: DAPI for nuclear staining

SPG3A Antibody (1B9) - H00051062-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B9

SPG3A Antibody (1B11) - H00051062-M10 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B11
Western Blot: SPG3A Antibody (1B11) [H00051062-M10] - Analysis of SPG3A expression in PC-12 (Cat # L012V1).

SPG3A Antibody - NBP1-90234 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SPG3A Antibody [NBP1-90234] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

SPG3A Antibody - H00051062-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal
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