CYP26B1

Gene Symbol	CYP26B1
Entrez Gene	56603
Alt Symbol	CYP26A2, P450RAI-2, P450RAI2, RHFCA
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 26, subfamily B, polypeptide 1
Other Description	cytochrome P450 26B1|cytochrome P450 retinoic acid-inactivating 2|cytochrome P450 retinoid metabolizing protein|cytochrome P450, subfamily XXVIB, polypeptide 1|retinoic acid-metabolizing cytochrome
Swissprots	B7Z2K6 B7Z3B8 E4W5W7 Q9NR63 B2R8M7 B7Z2P4 Q32MC0 Q53TW1 Q9NP41
Accessions	AAY14690 EAW99761 Q9NR63 AA484668 AF252297 AAF76003 AK294814 BAH11892 AK294933 BAH11930 AK295683 BAH12154 AK313433 BAG36224 AW873673 BC069443 AAH69443 BC109205 AAI09206 CR749631 CAH18425 DC308258 FJ467289 ACR19332 XM_005264433 XP_005264490 XM_011532988 XP_011531290 NM_001277742 NP_001264671 NM_019885 NP_063938
Function	Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. {ECO:0000269|PubMed:10823918, ECO:0000269|PubMed:22019272}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in brain, particularly in the cerebellum and pons. {ECO:0000269|PubMed:10823918}.
Top Pathways	Retinol metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytochrome P450 26B full length protein - ab153422 from Abcam Category Protein Source Wheat germ Species Human

Human Cytochrome P450 26B protein fragment - ab153423 from Abcam Category Protein Source Wheat germ Species Human

CYP26B1 Antibody Blocking Peptide - LS-E26199 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP26B1 Antibody Blocking Peptide - LS-E9409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP26B1 Antibody Blocking Peptide - LS-E20933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP26B1 Antibody Blocking Peptide - LS-E20934 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cytochrome P450 26B1 Protein - H00056603-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Cytochrome P450 26B1 Partial Recombinant Protein - H00056603-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CYP26B1-Antibody-C-term-Blocking-Peptide - BP7994b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP26B1 blocking peptide - GTX89224-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Goat anti CYP26B1 antibody Immunizing peptide - orb17199 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

CYP26B1 Blocking Peptide - 33R-5404 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CYP26B1 Blocking Peptide - 33R-8748 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytochrome P450 26B Peptide - AC21-1030-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CYP26B1 - H00056603-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CYP26B1 - H00056603-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP26B1 - H00056603-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CYP26B1 Peptide - 45-447P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

CYP26B1 fusion protein - Ag17493 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CYP26B1 fusion protein - ag15368 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CYP26B1, His-tagged - CYP26B1-11769H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Cytochrome P450 26B1 (CYP26B1) - RPD541Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cytochrome P450 26B1 (CYP26B1) - RPD541Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cytochrome P450 26B1(CYP26B1) - CSB-YP885700HU CSB-EP885700HU CSB-BP885700HU CSB-MP885700HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cytochrome P450 26B1 Protein (Recombinant) - abx168263 from Abbexa Category Protein Source Human Species Human

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