| Gene Symbol |
ADRA1A
|
| Entrez Gene |
282134
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 1A
|
| Other Description |
adrenergic, alpha-1A-, receptor|alpha-1A adrenergic receptor|alpha-1A adrenoceptor|alpha-1A adrenoreceptor
|
| Swissprots |
P18130
|
| Accessions |
AAB20599 DAA26675 DAA26689 P18130 J05426 AAA30374 NM_174498 NP_776923
|
| Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
|
| Top Pathways |
Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway
|