Gene Symbol | DNAH8 |
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Entrez Gene | 1769 |
Alt Symbol | ATPase, hdhc9 |
Species | Human |
Gene Type | protein-coding |
Description | dynein, axonemal, heavy chain 8 |
Other Description | axonemal beta dynein heavy chain 8|ciliary dynein heavy chain 8|dynein heavy chain 8, axonemal|dynein, axonemal, heavy polypeptide 8 |
Swissprots | Q9UEM4 Q5T2M3 O00438 Q5T2M4 Q96JB1 Q5TG00 Q5JYI2 |
Accessions | EAX03966 EAX03967 Q96JB1 AF356519 AAK60620 AF527621 AAN34632 AF527622 AAN34633 AF527623 AAN34634 AJ132091 CAA10564 AK093434 AK093653 AK098716 AL042262 AW503176 Z83806 CAB06060 XM_011514318 XP_011512620 XM_011514319 XP_011512621 XM_011514320 XP_011512622 XM_011514321 XP_011512623 XM_011514322 XP_011512624 XR_926078 NM_001206927 NP_001193856 NM_001371 |
Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. |
Top Pathways | Huntington's disease |
DNAH8 CRISPR/Cas9 KO Plasmid (h) - sc-416654 from Santa Cruz Biotechnology
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DNAH8 HDR Plasmid (h) - sc-416654-HDR from Santa Cruz Biotechnology
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DNAH8 Double Nickase Plasmid (h) - sc-416654-NIC from Santa Cruz Biotechnology
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DNAH8 Double Nickase Plasmid (h2) - sc-416654-NIC-2 from Santa Cruz Biotechnology
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DNAH8 CRISPR Activation Plasmid (h) - sc-416654-ACT from Santa Cruz Biotechnology
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DNAH8 CRISPR Activation Plasmid (h2) - sc-416654-ACT-2 from Santa Cruz Biotechnology
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DNAH8 Lentiviral Activation Particles (h) - sc-416654-LAC from Santa Cruz Biotechnology
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DNAH8 Lentiviral Activation Particles (h2) - sc-416654-LAC-2 from Santa Cruz Biotechnology
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DNAH8 siRNA (h) - sc-95152 from Santa Cruz Biotechnology
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DNAH8 shRNA Plasmid (h) - sc-95152-SH from Santa Cruz Biotechnology
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DNAH8 shRNA (h) Lentiviral Particles - sc-95152-V from Santa Cruz Biotechnology
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ATPase RNAi - H00001769-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7336 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7336 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03888 from Sigma-Aldrich
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DNAH8 siRNA (Human) - CRH1229 from Cohesion Biosciences
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DNAH8 - MBS8211970 from MyBioSource
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Human DNAH8 siRNA - orb261731 from Biorbyt
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DNAH8 shRNA Plasmid (Human) - CHH1229 from Cohesion Biosciences
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