CIITA

Gene Symbol	CIITA
Entrez Gene	4261
Alt Symbol	C2TA, CIITAIV, MHC2TA, NLRA
Species	Human
Gene Type	protein-coding
Description	class II, major histocompatibility complex, transactivator
Other Description	MHC class II transactivator|MHC class II transactivator type III|NLR family, acid domain containing|nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Swissprots	Q96KL4 P33076 Q8SNB8 D3DUG0 A0N0N9 E9PFE0 Q29675
Accessions	AAB92363 AAC39714 ABK41930 CDL97011 EAW85168 EAW85169 EAW85170 EAW85171 EAW85172 EAW85173 EAW85174 P33076 AF410154 AAL04118 AY084054 AAM15723 AY084055 AAM15724 AY699071 AAU06586 BC172348 AAI72348 BE247223 BM193016 HG507727 U18259 AAA88861 U18288 AAA88862 U31931 AAA92364 X74301 CAA52354 XM_006720880 XP_006720943 XM_011522484 XP_011520786 XM_011522485 XP_011520787 XM_011522486 XP_011520788 XM_011522487 XP_011520789 XM_011522488 XP_011520790 XM_011522489 XP_011520791 XM_011522490 XP_011520792 XM_011522491 XP_011520793 XM_011522492 XP_011520794 XM_011522493 XP_011520795 XM_011522494 XP_011520796 XM_011522495 XP_011520797 XM_011522496 XP_011520798 XR_932841 XR_932842 XR_932843 XR_932846 XR_932847 XR_932848 NM_000246 NP_000237 NM_001286402 NP_001273331 NM_001286403 NP_001273332 NR_104444
Function	Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). {EC
Subcellular Location	Nucleus {ECO:0000269|PubMed:23007646}. Nucleus, PML body {ECO:0000269|PubMed:23007646}. Note=Recruited to PML body by PML.
Top Pathways	Primary immunodeficiency, Toxoplasmosis, Influenza A, Tuberculosis, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

CIITA CRISPR/Cas9 KO Plasmid (h) - sc-401762 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA HDR Plasmid (h) - sc-401762-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA Double Nickase Plasmid (h) - sc-401762-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA Double Nickase Plasmid (h2) - sc-401762-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA CRISPR Activation Plasmid (h) - sc-401762-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA CRISPR Activation Plasmid (h2) - sc-401762-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA Lentiviral Activation Particles (h) - sc-401762-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA Lentiviral Activation Particles (h2) - sc-401762-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CIITA siRNA (h) - sc-37739 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CIITA shRNA Plasmid (h) - sc-37739-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CIITA shRNA (h) Lentiviral Particles - sc-37739-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CIITA RNAi - H00004261-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU150591 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6134 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6134 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CIITA siRNA (Human) - CRH2898 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CIITA - MBS8213936 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CIITA (NM_000246.3) - SHH264085 from Creative biogene Category siRNA Species Reactivities Human

Human CIITA siRNA - orb263400 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CIITA shRNA Plasmid (Human) - CHH2898 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CIITA miRNA 3'UTR clone - MiUTR1H-02167 from Creative biogene Species Reactivities Human

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