Gene Symbol | KYNU |
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Entrez Gene | 8942 |
Alt Symbol | KYNUU |
Species | Human |
Gene Type | protein-coding |
Description | kynureninase |
Other Description | L-kynurenine hydrolase |
Swissprots | B2RCZ5 Q9BVW3 D3DP79 Q6I9T2 Q16719 |
Accessions | AAX93159 AAY14727 EAX11599 EAX11600 EAX11601 Q16719 AK223426 BAD97146 AK290900 BAF83589 AK292095 BAF84784 AK315343 BAG37742 AL548658 AW290980 AW296221 BC000879 AAH00879 CB151988 CR457423 CAG33704 HQ447861 ADQ32345 U57721 AAC50650 XM_011512101 XP_011510403 XM_011512102 XP_011510404 XM_011512103 XP_011510405 XM_011512104 XP_011510406 XM_011512105 XP_011510407 XR_923058 NM_001032998 NP_001028170 NM_001199241 NP_001186170 NM_003937 NP_003928 |
Function | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}. |
Tissue Specificity | Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
Top Pathways | Tryptophan metabolism |
kynureninase CRISPR/Cas9 KO Plasmid (h) - sc-405705 from Santa Cruz Biotechnology
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kynureninase HDR Plasmid (h) - sc-405705-HDR from Santa Cruz Biotechnology
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kynureninase Double Nickase Plasmid (h) - sc-405705-NIC from Santa Cruz Biotechnology
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kynureninase Double Nickase Plasmid (h2) - sc-405705-NIC-2 from Santa Cruz Biotechnology
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kynureninase CRISPR Activation Plasmid (h) - sc-405705-ACT from Santa Cruz Biotechnology
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kynureninase CRISPR Activation Plasmid (h2) - sc-405705-ACT-2 from Santa Cruz Biotechnology
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kynureninase Lentiviral Activation Particles (h) - sc-405705-LAC from Santa Cruz Biotechnology
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kynureninase Lentiviral Activation Particles (h2) - sc-405705-LAC-2 from Santa Cruz Biotechnology
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kynureninase siRNA (h) - sc-95023 from Santa Cruz Biotechnology
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kynureninase shRNA Plasmid (h) - sc-95023-SH from Santa Cruz Biotechnology
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kynureninase shRNA (h) Lentiviral Particles - sc-95023-V from Santa Cruz Biotechnology
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Kynureninase RNAi - H00008942-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11509 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11509 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01081 from Sigma-Aldrich
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KYNU siRNA (Human) - CRH5915 from Cohesion Biosciences
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Kynureninase RNAi - H00008942-R02 from Novus Biologicals
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shRNA set against Human KYNU (NM_003937.2) - SHH327967 from Creative biogene
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shRNA set against Human KYNU(NM_003937.2) - SHH140411 from Creative biogene
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shRNA set against Human KYNU(NM_001032998.1) - SHH140447 from Creative biogene
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Human KYNU siRNA - orb266417 from Biorbyt
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KYNU shRNA Plasmid (Human) - CHH5915 from Cohesion Biosciences
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KYNU miRNA 3'UTR clone - MiUTR1H-05544 from Creative biogene
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KYNU miRNA 3'UTR clone - MiUTR1H-05545 from Creative biogene
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