Gene Symbol | NT5E |
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Entrez Gene | 4907 |
Alt Symbol | CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT |
Species | Human |
Gene Type | protein-coding |
Description | 5'-nucleotidase, ecto (CD73) |
Other Description | 5'-NT|5'-nucleotidase|Purine 5-Prime-Nucleotidase|ecto-5'-nucleotidase |
Swissprots | P21589 Q5W116 B3KQI8 O75520 |
Accessions | AAA96950 AAC98672 AAQ21035 CAF86213 CDM22274 EAW48634 EAW48635 EAW48636 P21589 AK075008 BAG52050 AK075083 BAG52063 AK314661 BAG37219 BC015940 AAH15940 BC065937 AAH65937 BQ019358 DA574510 DQ186653 ABA39834 X55740 CAA39271 NM_001204813 NP_001191742 NM_002526 NP_002517 |
Function | Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. {ECO:0000269|PubMed:21933152}. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |
CD73 CRISPR/Cas9 KO Plasmid (h) - sc-400307 from Santa Cruz Biotechnology
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CD73 HDR Plasmid (h) - sc-400307-HDR from Santa Cruz Biotechnology
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CD73 Double Nickase Plasmid (h) - sc-400307-NIC from Santa Cruz Biotechnology
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CD73 Double Nickase Plasmid (h2) - sc-400307-NIC-2 from Santa Cruz Biotechnology
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CD73 CRISPR Activation Plasmid (h) - sc-400307-ACT from Santa Cruz Biotechnology
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CD73 CRISPR Activation Plasmid (h2) - sc-400307-ACT-2 from Santa Cruz Biotechnology
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CD73 Lentiviral Activation Particles (h) - sc-400307-LAC from Santa Cruz Biotechnology
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CD73 Lentiviral Activation Particles (h2) - sc-400307-LAC-2 from Santa Cruz Biotechnology
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CD73 siRNA (h) - sc-42862 from Santa Cruz Biotechnology
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CD73 shRNA Plasmid (h) - sc-42862-SH from Santa Cruz Biotechnology
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CD73 shRNA (h) Lentiviral Particles - sc-42862-V from Santa Cruz Biotechnology
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5'-Nucleotidase/CD73 RNAi - H00004907-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023471 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0370 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0371 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0372 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15555 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15555 from Sigma-Aldrich
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NT5E siRNA (Human) - CRH3261 from Cohesion Biosciences
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shRNA set against Human NT5E (NM_002526.3) - SHH355616 from Creative biogene
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Human CD73 siRNA - orb263763 from Biorbyt
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NT5E shRNA Plasmid (Human) - CHH3261 from Cohesion Biosciences
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NT5E miRNA 3'UTR clone - MiUTR3H-00697 from Creative biogene
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