Gene Symbol | TOR1B |
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Entrez Gene | 27348 |
Alt Symbol | DQ1 |
Species | Human |
Gene Type | protein-coding |
Description | torsin family 1, member B (torsin B) |
Other Description | torsin ATPase-1B|torsin family 1 member B|torsin-1B |
Swissprots | O14657 |
Accessions | EAW87906 O14657 AF007872 AAC51733 AF317129 AAG50271 BC006480 AAH06480 BC015578 AAH15578 DQ893204 ABM84130 DQ893205 ABM84131 DQ893696 ABM84622 DQ896532 ABM87531 DQ896533 ABM87532 DQ896867 ABM87866 XM_005251927 XP_005251984 XR_929765 NM_014506 NP_055321 |
Function | May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000269|PubMed:15147511}. Nucleus membrane {ECO:0000269|PubMed:15147511}. |
Tissue Specificity | Widely expressed with low levels in brain. {ECO:0000269|PubMed:15147511}. |
TorsinB CRISPR/Cas9 KO Plasmid (h) - sc-407379 from Santa Cruz Biotechnology
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TorsinB HDR Plasmid (h) - sc-407379-HDR from Santa Cruz Biotechnology
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TorsinB Double Nickase Plasmid (h) - sc-407379-NIC from Santa Cruz Biotechnology
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TorsinB Double Nickase Plasmid (h2) - sc-407379-NIC-2 from Santa Cruz Biotechnology
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TorsinB CRISPR Activation Plasmid (h) - sc-407379-ACT from Santa Cruz Biotechnology
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TorsinB CRISPR Activation Plasmid (h2) - sc-407379-ACT-2 from Santa Cruz Biotechnology
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TorsinB Lentiviral Activation Particles (h) - sc-407379-LAC from Santa Cruz Biotechnology
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TorsinB Lentiviral Activation Particles (h2) - sc-407379-LAC-2 from Santa Cruz Biotechnology
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TorsinB siRNA (h) - sc-92951 from Santa Cruz Biotechnology
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TorsinB shRNA Plasmid (h) - sc-92951-SH from Santa Cruz Biotechnology
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TorsinB shRNA (h) Lentiviral Particles - sc-92951-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU069621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21835 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21835 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10281 from Sigma-Aldrich
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TOR1B siRNA (Human) - CRH9097 from Cohesion Biosciences
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TOR1B - MBS8239243 from MyBioSource
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TorsinB CRISPR/Cas9 KO Plasmid (h2) - sc-407379-KO-2 from Santa Cruz Biotechnology
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TorsinB HDR Plasmid (h2) - sc-407379-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TOR1B (NM_014506.1) - SHH432968 from Creative biogene
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shRNA set against Human TOR1B(NM_014506.1) - SHL087870 from Creative biogene
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Human TOR1B siRNA - orb269599 from Biorbyt
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TOR1B shRNA Plasmid (Human) - CHH9097 from Cohesion Biosciences
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TOR1B miRNA 3'UTR clone - MiUTR1H-10647 from Creative biogene
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