| Gene Symbol |
ATG13
|
| Entrez Gene |
9776
|
| Alt Symbol |
KIAA0652, PARATARG8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 13
|
| Other Description |
ATG13 autophagy related 13 homolog|autophagy-related protein 13
|
| Swissprots |
Q9BRL3 B4DFI4 Q9H8B0 D3DQQ2 D3DQQ1 E9PQZ8 Q53EN6 O75143
|
| Accessions |
EAW67985 EAW67986 EAW67987 EAW67988 EAW67989 EAW67990 EAW67991 O75143 AB014552 BAA31627 AF052175 AK000705 AK023867 BAB14707 AK223603 BAD97323 AK289641 BAF82330 AK293109 BAF85798 AK294110 BAG57445 AK296526 BAG59157 AK315925 BAH14296 BC001331 AAH01331 BC002378 AAH02378 BC006191 AAH06191 CD675643 DA195671 GQ129361 ACT64495 GQ129362 ACT64496 HQ448260 ADQ32740 XM_005253262 XP_005253319 XM_005253263 XP_005253320 XM_005253265 XP_005253322 XM_005253266 XP_005253323 XM_005253268 XP_005253325 XM_006718394 XP_006718457 XM_006718395 XP_006718458 XM_006718396 XP_006718459 XM_011520493 XP_011518795 XM_011520494 XP_011518796 XM_011520495 XP_011518797 XM_011520496 XP_011518798 XM_011520497 XP_011518799 XM_011520498 XP_011518800 XM_011520499 XP_011518801 XM_011520500 XP_011518802 XM_011520501 XP_011518803 XM_011520502 XP_011518804 XM_011520503 XP_011518805 NM_001142673 NP_001136145 NM_001205119 NP_001192048 NM_001205120 NP_001192049 NM_001205121 NP_001192050 NM_001205122 NP_001192051 NM_014741 NP_055556
|
| Function |
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.
|
| Top Pathways |
Regulation of autophagy
|
