| Gene Symbol |
CDC42EP2
|
| Entrez Gene |
10435
|
| Alt Symbol |
BORG1, CEP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC42 effector protein (Rho GTPase binding) 2
|
| Other Description |
CRIB-containing BOGR1 protein|binder of Rho GTPases 1|cdc42 effector protein 2
|
| Swissprots |
Q9UNS0 B2RD85 O14613
|
| Accessions |
AAN39381 EAW74374 O14613 AF001436 AAB81206 AF098290 AAD16185 AF163840 AAD48784 AK098292 BAG53607 AK315444 BAG37832 BC022337 AAH22337 BC075834 AAH75834 BT020004 AAV38807 DA251345 DQ891988 ABM82914 DQ895178 ABM86104 NM_006779 NP_006770
|
| Function |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}.
|
| Tissue Specificity |
Highly expressed in the heart. Weakly expressed in the pancreas and liver. {ECO:0000269|PubMed:10490598}.
|
![Western Blot: CDC42EP2 Overexpression Lysate (Adult Normal) [NBL1-09008] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC42EP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2473_CDC42EP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09008-img0002.jpg)