NR5A2

Gene Symbol	NR5A2
Entrez Gene	2494
Alt Symbol	B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 5, group A, member 2
Other Description	CYP7A promoter-binding factor|alpha-1-fetoprotein transcription factor|b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus|fetoprotein-alpha 1 (AFP) transcription factor|hepatocytic transcription factor hB1F-3|liver nuclear receptor homolog-1 variant 2|liver receptor homolog 1|liver receptor homolog-1|nuclear receptor NR5A2|nuclear receptor subfamily 5 group A member 2
Swissprots	Q147U3 O95642 B4E2P3 O00482
Accessions	AAG17124 AAG17125 AAL37171 ACD87739 EAW91305 EAW91306 EAW91307 EAW91308 O00482 AB019246 BAA34092 AB307719 BAH02310 AF049102 AAD03248 AF112344 AF124247 AAD26565 AF124248 AAD26566 AF146343 AAD37378 AF228413 AK304344 BAG65188 AK304365 BAG65205 AK308446 AK316513 BAH14884 BC027893 BC118571 AAI18572 BC118652 AAI18653 CA776772 CB162803 HQ692857 ADZ17368 U80251 AAC78727 U93553 AAD03155 XM_005245062 XP_005245119 XM_011509380 XP_011507682 XM_011509381 XP_011507683 XM_011509382 XP_011507684 XM_011509383 XP_011507685 XM_011509384 XP_011507686 NM_001276464 NP_001263393 NM_003822 NP_003813 NM_205860 NP_995582
Function	Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
Top Pathways	Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NR5A2 / LRH1 full length protein - ab81844 from Abcam Category Protein Source E. coli Species Human

Human NR5A2 / LRH1 full length protein - ab82070 from Abcam Category Protein Source Baculovirus Species Human

NR5A2 / LRH1 peptide - ab169741 from Abcam Category Peptide

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E4638 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E11409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E13786 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E13787 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E28556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A2 / LRH-1 Blocking Peptide - LS-E28557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E28569 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR5A2 / LRH-1 Antibody Blocking Peptide - LS-E13410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LRH-1/NR5A2 Protein - H00002494-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LRH-1/NR5A2 Protein - H00002494-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NR5A2-Antibody-Center-Blocking-Peptide - BP17000c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NR5A2 / CPF - H00002494-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NR5A2 / CPF - H00002494-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NR5A2 / CPF - H00002494-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NR5A2 / CPF - H00002494-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NR5A2 fusion protein - Ag19323 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NR5A2 fusion protein - ag18001 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NR5A2 - NR5A2-1052H from Creative Biomart Category Protein Source Baculovirus.

Recombinant Human NR5A2, His-tagged - NR5A2-2505H from Creative Biomart Category Protein Source Baculovirus.

Recombinant Human NR5A2, GST-tagged - NR5A2-1053H from Creative Biomart Category Protein Source E. coli.

Recombinant Human NR5A2 - NR5A2-30410TH from Creative Biomart Category Protein Source E. coli

Recombinant Human NR5A2, His-tagged - NR5A2-30453TH from Creative Biomart Category Protein

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