| Gene Symbol | RAB7A |
|---|---|
| Entrez Gene | 100008682 |
| Alt Symbol | RAB7 |
| Species | Rabbit |
| Gene Type | protein-coding |
| Description | RAB7A, member RAS oncogene family |
| Other Description | ras-related protein Rab-7a |
| Swissprots | O97572 |
| Accessions | O97572 AF050174 AAD02564 XM_008260198 XP_008258420 NM_001082034 NP_001075503 |
| Function | Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the li |
| Subcellular Location | Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Melanosome {ECO:0000250}. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}. |
| Top Pathways | Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis |
Recombinant Rabbit Ras-related protein Rab-7a(RAB7A) - CSB-YP019219RB CSB-EP019219RB CSB-BP019219RB CSB-MP019219RB from Cusabio
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Ras-related protein Rab-7a (RAB7A), Recombinant Protein - MBS1149095 from MyBioSource
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