Gene Symbol | FBP1 |
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Entrez Gene | 100008863 |
Alt Symbol | - |
Species | Rabbit |
Gene Type | protein-coding |
Description | fructose-1,6-bisphosphatase 1 |
Other Description | - |
Swissprots | P00637 |
Accessions | AJ300657 CAC19334 GBCK01247372 XM_002708294 XP_002708340 |
Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain (By similarity). {ECO:0000250}. |
Top Pathways | Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Carbon metabolism |
Recombinant Rabbit Fructose-1,6-bisphosphatase 1(FBP1) - CSB-YP008459RB CSB-EP008459RB CSB-BP008459RB CSB-MP008459RB from Cusabio
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Fructose-1,6-bisphosphatase 1 (FBP1), Recombinant Protein - MBS950558 from MyBioSource
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