HSPA5

Gene Symbol	HSPA5
Entrez Gene	3309
Alt Symbol	BIP, GRP78, HEL-S-89n, MIF2
Species	Human
Gene Type	protein-coding
Description	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Other Description	78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|epididymis secretory sperm binding protein Li 89n|immunoglobulin heavy chain-binding protein
Swissprots	Q9UK02 Q9NPF1 Q2EF78 P11021 B0QZ61
Accessions	AAA52614 ABD04090 CAA42595 CAK18759 EAW87620 EAW87621 P11021 AA433933 AF188611 AAF13605 AF216292 AAF42836 AJ271729 CAB71335 AK129617 AK293604 BAG57068 BC020235 AAH20235 DA549454 DQ892173 ABM83099 DQ895368 ABM86294 EU794617 ACJ13671 X87949 CAA61201 NM_005347 NP_005338
Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. {ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668}.
Subcellular Location	Endoplasmic reticulum lumen. Melanosome. Cytoplasm {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways	Protein export, Prion diseases, Protein processing in endoplasmic reticulum, Thyroid hormone synthesis, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRP 78 CRISPR/Cas9 KO Plasmid (h) - sc-400073 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 HDR Plasmid (h) - sc-400073-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 Double Nickase Plasmid (h) - sc-400073-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 Double Nickase Plasmid (h2) - sc-400073-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 CRISPR Activation Plasmid (h) - sc-400073-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 CRISPR Activation Plasmid (h2) - sc-400073-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 Lentiviral Activation Particles (h) - sc-400073-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 Lentiviral Activation Particles (h2) - sc-400073-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRP 78 siRNA (h) - sc-29338 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRP 78 shRNA Plasmid (h) - sc-29338-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRP 78 shRNA (h) Lentiviral Particles - sc-29338-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRP 78 siRNA (h2) - sc-44261 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRP 78 shRNA Plasmid (h2) - sc-44261-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRP 78 shRNA (h2) Lentiviral Particles - sc-44261-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU109691 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10365 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10365 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

HSPA5 siRNA (Human) - CRH2263 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GRP78/HSPA5 RNAi - H00003309-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HSPA5 - MBS828388 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HSPA5 (NM_005347.4) - SHH315613 from Creative biogene Category siRNA Species Reactivities Human

Human HSPA5 siRNA - orb262765 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HSPA5 shRNA Plasmid (Human) - CHH2263 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HSPA5 miRNA 3'UTR clone - MiUTR3H-00872 from Creative biogene Species Reactivities Human

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