| Gene Symbol | HSPA5 |
|---|---|
| Entrez Gene | 3309 |
| Alt Symbol | BIP, GRP78, HEL-S-89n, MIF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
| Other Description | 78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|epididymis secretory sperm binding protein Li 89n|immunoglobulin heavy chain-binding protein |
| Swissprots | Q9UK02 Q9NPF1 Q2EF78 P11021 B0QZ61 |
| Accessions | AAA52614 ABD04090 CAA42595 CAK18759 EAW87620 EAW87621 P11021 AA433933 AF188611 AAF13605 AF216292 AAF42836 AJ271729 CAB71335 AK129617 AK293604 BAG57068 BC020235 AAH20235 DA549454 DQ892173 ABM83099 DQ895368 ABM86294 EU794617 ACJ13671 X87949 CAA61201 NM_005347 NP_005338 |
| Function | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. {ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668}. |
| Subcellular Location | Endoplasmic reticulum lumen. Melanosome. Cytoplasm {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Top Pathways | Protein export, Prion diseases, Protein processing in endoplasmic reticulum, Thyroid hormone synthesis, Antigen processing and presentation |