| Gene Symbol |
Got2
|
| Entrez Gene |
25721
|
| Alt Symbol |
ASPATA
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamic-oxaloacetic transaminase 2, mitochondrial
|
| Other Description |
FABP-1|FABPpm|Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2)|aspartate aminotransferase, mitochondrial|fatty acid-binding protein|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A
|
| Swissprots |
Q64551 Q9QV50 P00507
|
| Accessions |
CBF96250 CBV09770 EDL87266 P00507 BC061792 AAH61792 CB607680 FM056810 FQ210345 M12709 AAA41267 M18467 AAB54275 NM_013177 NP_037309
|
| Function |
Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:11962739}. Cell membrane {ECO:0000269|PubMed:11962739}. Note=Located in the mitochondria of liver, pancreas, spleen, heart, pituitary gland and submandibular gland cells. In kidney, located in the mitochondria, on the cell surface of regions with protrusions in distal tubules, on the apical cell surface of protrusions along the microvilli in cortical collecting ducts, in condensing vacuoles, on the cell surface at cell boundaries of adjoining kidney cells and on the cell surface of endothelial cells lining capillaries in the glomerulus. Also located at the cell surface of endothelial cells lining arterioles and on the cell surface of lymphocytes.
|
| Tissue Specificity |
Expressed in all tissues tested: liver, pancreas, kidney, heart, spleen, arterioles, and lymphocytes. {ECO:0000269|PubMed:11962739}.
|
| Top Pathways |
Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism
|