ABCA4

Gene Symbol	ABCA4
Entrez Gene	24
Alt Symbol	ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family A (ABC1), member 4
Other Description	ATP binding cassette transporter|ATP-binding cassette sub-family A member 4|ATP-binding cassette transporter, retinal-specific|ATP-binding transporter, retina-specific|RIM ABC transporter|RIM protein|photoreceptor rim protein|retina-specific ABC transporter|retinal-specific ATP-binding cassette transporter|stargardt disease protein
Swissprots	Q0QD48 O60438 P78363 Q4LE31 O15112 O60915
Accessions	AAP33155 CAA75729 EAW73056 EAW73057 EAW73058 P78363 AB210040 BAE06122 AF000148 AAC23915 AF001945 AAC05632 AK295818 BAG58635 AK296896 BAH12450 AK301733 BAG63198 AK301764 BAG63224 AK310492 AL712362 BC172262 AAI72262 BC172565 AAI72565 BM686882 CR627391 CAH10486 DQ426859 ABD90529 U66691 U88667 AAC51144 NM_000350 NP_000341
Function	In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO:0000269|PubMed:10075733}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10075733}; Multi-pass membrane protein {ECO:0000269|PubMed:10075733}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Tissue Specificity	Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human ABCA4 ELISA Kit (Sandwich ELISA) - LS-F9064 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.123 ng/ml Range 0.313-20 ng/ml

Human ABCA4 ELISA Kit - abx150500 from Abbexa Category ELISA Kit Sensitivity 0.112 ng/ml Range 0.313 ng/ml - 20 ng/ml

ATP Binding Cassette Transporter A4 (ABCA4), Human, ELISA Kit - SED620Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

ATP-binding cassette, sub-family A (ABC1) , member 4, ELISA Kit - MBS9326547 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for ATP Binding Cassette Transporter A4 (ABCA4) - SED620Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.123ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for ATP Binding Cassette Transporter A4 (ABCA4) - SED620Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.123ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ATP Binding Cassette Transporter A4 (ABCA4), Human, ELISA Kit - DL-ABCA4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human ABCA4 ELISA Kit - abx573043 from Abbexa Category ELISA Kit Sensitivity 0.112 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human ABCA4 ELISA Kit - E003991 from Biobool Category ELISA Kit Sensitivity Typically less than 0.123ng/mL.

ABCA4 ELISA Kit (Human) (OKCD00914) - OKCD00914 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.123 ng/mL Range 0.312-20 ng/mL

anti-ABCA4 (Rim Protein) antibody [3F4] - ARG52222 from Arigo Biolaboratories Category ELISA Kit

Human Retinal-specific ATP-binding cassette transporter (ABCA4) ELISA Kit - AE23075HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.123 ng/mL Range 0.312-20 ng/mL

ATP Binding Cassette Transporter A4 (ABCA4), ELISA Kit - MBS454206 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.112ng/mL Range 0.312-20ng/mL

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