PHACTR4

Gene Symbol PHACTR4
Entrez Gene 65979
Alt Symbol PPP1R124
Species Human
Gene Type protein-coding
Description phosphatase and actin regulator 4
Other Description protein phosphatase 1, regulatory subunit 124
Swissprots Q6NUN6 Q8N384 A2APK6 Q9H8W6 Q8IZ21 B9ZVW0 Q9H395 D3DPM3 Q68DD4 Q9H6X0
Accessions CBX47623 CBX47624 EAX07696 EAX07697 EAX07698 Q8IZ21 AA973468 AF130081 AAG35507 AK023233 BAB14483 AK024663 AK025436 BAB15130 AL705720 BC016152 BC021247 AAH21247 BC029266 AAH29266 BC068508 AAH68508 CR749449 CAH18286 DA586663 JF432272 ADZ15489 XM_005245970 XP_005246027 XM_006710842 XP_006710905 XM_006710843 XP_006710906 XM_006710844 XP_006710907 XM_006710845 XP_006710908 XM_006710846 XP_006710909 XM_006710847 XP_006710910 XM_006710848 XP_006710911 XM_006710850 XP_006710913 XM_006710851 XP_006710914 XM_006710852 XP_006710915 XM_011542028 XP_011540330 XM_011542029 XP_011540331 XM_011542030 XP_011540332 XM_011542031 XP_011540333 NM_023923 NP_076412 NM_001048183 NP_001041648
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.

PHACTR4 (H-65) - sc-292111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PHACTR4 (H-65): sc-292111. Western blot analysis of PHACTR4 expression in non-transfected 293T: sc-117752 (A), human PHACTR4 transfected 293T: sc-373558 (B) and HeLa (C) whole cell lysates.

PHACTR4 (K-17) - sc-103818 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PHACTR4 (W-13) - sc-103820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PHACTR4 antibody - ab118474 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PHACTR4 antibody (ab118474) at 1/500 dilutionLane 1 : MCF7 cell lysateLane 2 : Human fetal spleen lysateLane 3 : Human fetal liver lysate

Anti-PHACTR4 antibody - ab124479 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PHACTR4 antibody (ab124479) at 1/500 dilutionLane 1 : Human fetal testis lysate Lane 2 : MCF7 cell lysate

Anti-PHACTR4 antibody - ab103187 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PHACTR4 antibody (ab103187) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

Anti-PHACTR4 antibody - ab137965 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PHACTR4 antibody (ab137965) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-PHACTR4 antibody [EP12543] - ab192882 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP12543
Anti-PHACTR4 antibody [EP12543] (ab192882) at 1/10000 dilution + SH-SY5Y cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-PHACTR4 Antibody (aa536-565, FITC) - LS-C216734 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565, AP) - LS-C216731 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565, APC) - LS-C216732 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565, Biotin) - LS-C216733 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565, Azide-free, HRP) - LS-C216735 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565, PE) - LS-C216736 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa346-395) - LS-C200484 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using PHACTR4 antibody.

Anti-PHACTR4 Antibody (aa543-572) - LS-C323978 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa139-378) - LS-C178889 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa139-378) - LS-C178615 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PHACTR4 Antibody (aa536-565) - LS-C163559 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from human kidney tissue lysate, using PHAR4 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

PHACTR4 Antibody - NBP1-82267 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PHACTR4 Antibody [NBP1-82267] - Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

ANTI-PHAR4 (C-TERM) antibody produced in rabbit - SAB1304443 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PHAR4 (C-term): <B>Cat. No. SAB1304443</B>: Western blot analysis of PHAR4 Antibody (C-term) in mouse spleen tissue lysates (35 μg/lane).

Anti-PHACTR4 antibody produced in rabbit - HPA028985 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PHACTR4: <B>Cat. No. HPA028985</B>: Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.

PHACTR4 Antibody - C-terminal region (ARP67740_P050) - ARP67740_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PHAR4-Antibody-C-term - AP9904b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from human kidney tissue lysate, using PHAR4 Antibody (C-term)(Cat. #AP9904b). AP9904b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

PHACTR4 Antibody - C-terminal region (OAAB06502) - OAAB06502 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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