| Gene Symbol | Got1 |
|---|---|
| Entrez Gene | 14718 |
| Alt Symbol | AI789014, Got-1, cAspAT, cCAT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 1, soluble |
| Other Description | aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A |
| Swissprots | Q3UJH8 P05201 |
| Accessions | CAA30275 EDL41904 P05201 AK146445 BAE27177 AK147807 AK147934 AK186873 AK192547 AK195432 AK203412 AK212371 AV574373 BC002057 AAH02057 BY441762 CK334037 J02623 AAA37263 XR_386441 NM_010324 NP_034454 |
| Function | Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. {ECO:0000269|PubMed:21937432}. |
| Top Pathways | Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism |
AATC CRISPR/Cas9 KO Plasmid (m) - sc-420627 from Santa Cruz Biotechnology
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AATC HDR Plasmid (m) - sc-420627-HDR from Santa Cruz Biotechnology
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AATC Double Nickase Plasmid (m) - sc-420627-NIC from Santa Cruz Biotechnology
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AATC Double Nickase Plasmid (m2) - sc-420627-NIC-2 from Santa Cruz Biotechnology
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AATC CRISPR Activation Plasmid (m) - sc-420627-ACT from Santa Cruz Biotechnology
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AATC CRISPR Activation Plasmid (m2) - sc-420627-ACT-2 from Santa Cruz Biotechnology
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AATC Lentiviral Activation Particles (m) - sc-420627-LAC from Santa Cruz Biotechnology
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AATC Lentiviral Activation Particles (m2) - sc-420627-LAC-2 from Santa Cruz Biotechnology
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AATC siRNA (m) - sc-45603 from Santa Cruz Biotechnology
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AATC shRNA Plasmid (m) - sc-45603-SH from Santa Cruz Biotechnology
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AATC shRNA (m) Lentiviral Particles - sc-45603-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU029631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32643 from Sigma-Aldrich
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GOT1 siRNA (Mouse) - CRM1634 from Cohesion Biosciences
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GOT1 - MBS8217134 from MyBioSource
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shRNA set against Mouse GOT1 (NM_010324.2) - SHH305486 from Creative biogene
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shRNA set against Mouse Got1(NM_010324.2) - SHH094785 from Creative biogene
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GOT1 shRNA Plasmid (Mouse) - CHM1634 from Cohesion Biosciences
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GOT1 miRNA 3'UTR clone - MiUTR1M-05247 from Creative biogene
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