| Gene Symbol |
PRKCZ
|
| Entrez Gene |
100009538
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C, zeta
|
| Other Description |
nPKC-zeta|protein kinase C zeta type
|
| Swissprots |
O19111
|
| Accessions |
O19111 U78768 AAB67317 NM_001082758 NP_001076227
|
| Function |
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN p
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Cell junction {ECO:0000250}. Note=In the retina, localizes in the terminals of the rod bipolar cells. Associated with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). {ECO:0000250}.
|
| Top Pathways |
Tight junction, Hippo signaling pathway, Chemokine signaling pathway, Endocytosis, Type II diabetes mellitus
|