Gene Symbol | Nkx1-2 |
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Entrez Gene | 20231 |
Alt Symbol | Nkx-1.1, Nkx-1.2, Sax1 |
Species | Mouse |
Gene Type | protein-coding |
Description | NK1 transcription factor related, locus 2 (Drosophila) |
Other Description | NK1 transcription factor-related protein 2|homeobox protein SAX-1|spinal cord axial homeobox gene 1 |
Swissprots | Q9JKW5 Q9JKX1 A4QPC3 Q9JKX0 Q9JKW9 P42580 Q9JKW6 Q9JHF2 |
Accessions | AAB06948 AAF43669 EDL17732 EDL17733 P42580 AF222442 AF222444 AAF43671 AF222445 AAF43672 AF223361 AAF43673 AF223362 AAF43674 AF223363 AAF43675 AF223674 AAF43676 AF223675 AAF43677 BC139757 AAI39758 X75384 CAA53153 NM_009123 NP_033149 |
Function | May function in cell specification, particularly in the CNS. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain. {ECO:0000269|PubMed:10681422, ECO:0000269|PubMed:7669696}. |
NKX1-2 CRISPR/Cas9 KO Plasmid (m) - sc-422804 from Santa Cruz Biotechnology
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NKX1-2 HDR Plasmid (m) - sc-422804-HDR from Santa Cruz Biotechnology
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NKX1-2 Double Nickase Plasmid (m) - sc-422804-NIC from Santa Cruz Biotechnology
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NKX1-2 Double Nickase Plasmid (m2) - sc-422804-NIC-2 from Santa Cruz Biotechnology
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NKX1-2 CRISPR Activation Plasmid (m) - sc-422804-ACT from Santa Cruz Biotechnology
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NKX1-2 CRISPR Activation Plasmid (m2) - sc-422804-ACT-2 from Santa Cruz Biotechnology
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NKX1-2 Lentiviral Activation Particles (m) - sc-422804-LAC from Santa Cruz Biotechnology
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NKX1-2 Lentiviral Activation Particles (m2) - sc-422804-LAC-2 from Santa Cruz Biotechnology
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Nkx-1.2 siRNA (m) - sc-150002 from Santa Cruz Biotechnology
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Nkx-1.2 shRNA Plasmid (m) - sc-150002-SH from Santa Cruz Biotechnology
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Nkx-1.2 shRNA (m) Lentiviral Particles - sc-150002-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36482 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36482 from Sigma-Aldrich
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NKX1-2 siRNA (Mouse) - CRM3597 from Cohesion Biosciences
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shRNA set against Mouse Nkx1-2(NM_009123.2) - SHR011850 from Creative biogene
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NKX1-2 shRNA Plasmid (Mouse) - CHM3597 from Cohesion Biosciences
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NKX1-2 miRNA 3'UTR clone - MiUTR1M-07672 from Creative biogene
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