CD79A
| Gene Symbol | CD79A |
|---|---|
| Entrez Gene | 973 |
| Alt Symbol | IGA, MB-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD79a molecule, immunoglobulin-associated alpha |
| Other Description | B-cell antigen receptor complex-associated protein alpha chain|CD79a antigen (immunoglobulin-associated alpha)|MB-1 membrane glycoprotein|ig-alpha|membrane-bound immunoglobulin-associated protein|surface IgM-associated protein |
| Swissprots | A0N775 Q53FB8 P11912 |
| Accessions | AAA20495 AAA57274 CCF76935 CCF76936 EAW57075 EAW57076 P11912 AF283770 AAG15590 AK223371 BAD97091 AK315337 BAG37737 BC018964 BC113731 AAI13732 BC113733 AAI13734 HQ258131 ADR82885 M74721 AAA60270 M80462 AAA59556 M86921 AAA59557 S46706 AAB23558 S75217 AAB20812 S79248 AAC60653 X13451 CAA31802 X83540 CAA58523 NM_001783 NP_001774 NM_021601 NP_067612 |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}. |
| Tissue Specificity | B-cells. |
| Top Pathways | B cell receptor signaling pathway, Primary immunodeficiency |
CD79A CRISPR/Cas9 KO Plasmid (h) - sc-401827 from Santa Cruz Biotechnology
|
||||||||
CD79A HDR Plasmid (h) - sc-401827-HDR from Santa Cruz Biotechnology
|
||||||||
CD79A Double Nickase Plasmid (h) - sc-401827-NIC from Santa Cruz Biotechnology
|
||||||||
CD79A Double Nickase Plasmid (h2) - sc-401827-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CD79A CRISPR Activation Plasmid (h) - sc-401827-ACT from Santa Cruz Biotechnology
|
||||||||
CD79A CRISPR Activation Plasmid (h2) - sc-401827-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CD79A Lentiviral Activation Particles (h) - sc-401827-LAC from Santa Cruz Biotechnology
|
||||||||
CD79A Lentiviral Activation Particles (h2) - sc-401827-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CD79A siRNA (h) - sc-35025 from Santa Cruz Biotechnology
|
||||||||
CD79A shRNA Plasmid (h) - sc-35025-SH from Santa Cruz Biotechnology
|
||||||||
CD79A shRNA (h) Lentiviral Particles - sc-35025-V from Santa Cruz Biotechnology
|
||||||||
CD79A RNAi - H00000973-R03 from Novus Biologicals
|
||||||||
CD79A RNAi - H00000973-R04 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU007311 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5750 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5750 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03006 from Sigma-Aldrich
|
||||||||
CD79A siRNA (Human) - CRH0694 from Cohesion Biosciences
|
||||||||
CD79A - MBS8203203 from MyBioSource
|
||||||||
shRNA set against Human CD79A (NM_001783.3) - SHH259353 from Creative biogene
|
||||||||
shRNA set against Human CD79A(NM_001783.3) - SHG158995 from Creative biogene
|
||||||||
shRNA set against Human CD79A(NM_021601.3) - SHG159031 from Creative biogene
|
||||||||
Human CD79A siRNA - orb261196 from Biorbyt
|
||||||||
CD79A shRNA Plasmid (Human) - CHH0694 from Cohesion Biosciences
|
||||||||
CD79A miRNA 3'UTR clone - MiUTR1H-01903 from Creative biogene
|