| Gene Symbol | CD79A |
|---|---|
| Entrez Gene | 973 |
| Alt Symbol | IGA, MB-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD79a molecule, immunoglobulin-associated alpha |
| Other Description | B-cell antigen receptor complex-associated protein alpha chain|CD79a antigen (immunoglobulin-associated alpha)|MB-1 membrane glycoprotein|ig-alpha|membrane-bound immunoglobulin-associated protein|surface IgM-associated protein |
| Swissprots | A0N775 Q53FB8 P11912 |
| Accessions | AAA20495 AAA57274 CCF76935 CCF76936 EAW57075 EAW57076 P11912 AF283770 AAG15590 AK223371 BAD97091 AK315337 BAG37737 BC018964 BC113731 AAI13732 BC113733 AAI13734 HQ258131 ADR82885 M74721 AAA60270 M80462 AAA59556 M86921 AAA59557 S46706 AAB23558 S75217 AAB20812 S79248 AAC60653 X13451 CAA31802 X83540 CAA58523 NM_001783 NP_001774 NM_021601 NP_067612 |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}. |
| Tissue Specificity | B-cells. |
| Top Pathways | B cell receptor signaling pathway, Primary immunodeficiency |