MBNL3

Gene Symbol MBNL3
Entrez Gene 55796
Alt Symbol CHCR, MBLX, MBLX39, MBXL
Species Human
Gene Type protein-coding
Description muscleblind-like splicing regulator 3
Other Description Cys3His CCG1-required protein|muscleblind-like 3|muscleblind-like X-linked protein|muscleblind-like protein 3
Swissprots Q6UDQ1 Q9NUK0 Q5JXP4 Q5JXN8 Q9UF37 Q9H0Z7 Q5JXN9 Q8IUR4 Q8TAF4 Q8TAD9
Accessions EAX11778 EAX11779 EAX11780 Q9NUK0 AB077698 BAB85648 AB077699 BAB85649 AF467070 AAL87670 AF491305 AAM09533 AI633721 AJ427918 CAD20869 AJ427919 CAD20870 AK002178 BAA92124 AK300248 BAG62014 AK307194 AL133625 CAB63751 AW665447 AY072692 AAL65661 AY372211 AAQ75759 BC042090 AAH42090 BC074775 AAH74775 BC074776 AAH74776 BU569439 CR627122 DA832176 DB023330 DC380677 EU446986 ABZ92515 XM_005262431 XP_005262488 XM_005262432 XP_005262489 XM_005262433 XP_005262490 XM_005262434 XP_005262491 XM_005262435 XP_005262492 XM_005262436 XP_005262493 XM_005262437 XP_005262494 XM_005262438 XP_005262495 XM_005262439 XP_005262496 XM_005262440 XP_005262497 XM_005262441 XP_005262498 XM_005262442 XP_005262499 XM_006724766 XP_006724829 XM_011531363 XP_011529665 XM_011531364 XP_011529666 NM_001170701 NP_001164172 NM_001170702 NP_001164173 NM_001170703 NP_001164174 NM_001170704 NP_001164175 NM_018388 NP_060858 NM_133486 NP_597846
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. {ECO:0000269|PubMed:12297108, ECO:0000269|PubMed:15257297}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:11929853}. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Tissue Specificity Highly expressed in the placenta. {ECO:0000269|PubMed:11929853}.

Human MBNL3 full length protein - ab163227 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163227 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human MBNL3 protein fragment - ab163228 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163228 on a 12.5% SDS-PAGE stained with Coomassie Blue.

MBNL3 Antibody Blocking Peptide - LS-E2170 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human MBNL3 Protein - H00055796-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human MBNL3 Protein - H00055796-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

MBNL3-Antibody-Center-Blocking-peptide - BP13080c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MBNL3 - H00055796-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

MBNL3 - H00055796-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

MBNL3 - H00055796-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

MBNL3 - H00055796-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

MBNL3 fusion protein - ag20117 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

MBNL3 fusion protein - ag20113 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Muscleblind-like protein 3(MBNL3) - CSB-YP868322HU CSB-EP868322HU CSB-BP868322HU CSB-MP868322HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

MBNL3 (transcript variant G) - TP316043 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MBNL3

MBNL3 (transcript variant R) - TP316093 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MBNL3

MBNL3 (transcript variant 4) - TP329842 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MBNL3

MBNL3 (transcript variant 3) - TP329854 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MBNL3

MBNL3 Recombinant Protein Antigen - NBP1-85635PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MBNL3 Peptide, Human - M34GP09285H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Muscleblind-like protein 3 (MBNL3), Recombinant Protein - MBS1295312 from MyBioSource

Category Protein
Prices $1,120.00, $1,120.00, $1,350.00, $1,350.00, $1,775.00, $1,775.00, $2,240.00, $2,240.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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