Gene Symbol | Htr3a |
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Entrez Gene | 15561 |
Alt Symbol | 5-HT3 |
Species | Mouse |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 3A |
Other Description | 5-HT-3|5-HT3-A|5-HT3A|5-HT3R|5-hydroxytryptamine receptor 3|5-hydroxytryptamine receptor 3A|5HT3 serotonin receptor|serotonin receptor 3A|serotonin-gated ion channel receptor |
Swissprots | Q61226 Q61225 P23979 |
Accessions | AAB71735 CAA55870 CAA55871 CAA80453 EDL25712 EDL25713 EDL25714 P23979 AF513221 AAM47014 AY605711 AAT37716 BC144799 AAI44800 BC145743 AAI45744 BY274793 BY275174 CJ237116 M74425 AAA37124 X72395 CAA51089 XM_011242398 XP_011240700 NM_001099644 NP_001093114 NM_013561 NP_038589 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269|PubMed:12867984}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Brain, spinal cord, and heart. |
SR-3A CRISPR/Cas9 KO Plasmid (m) - sc-420996 from Santa Cruz Biotechnology
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SR-3A HDR Plasmid (m) - sc-420996-HDR from Santa Cruz Biotechnology
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SR-3A Double Nickase Plasmid (m) - sc-420996-NIC from Santa Cruz Biotechnology
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SR-3A Double Nickase Plasmid (m2) - sc-420996-NIC-2 from Santa Cruz Biotechnology
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SR-3A CRISPR Activation Plasmid (m) - sc-420996-ACT from Santa Cruz Biotechnology
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SR-3A CRISPR Activation Plasmid (m2) - sc-420996-ACT-2 from Santa Cruz Biotechnology
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SR-3A Lentiviral Activation Particles (m) - sc-420996-LAC from Santa Cruz Biotechnology
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SR-3A Lentiviral Activation Particles (m2) - sc-420996-LAC-2 from Santa Cruz Biotechnology
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SR-3A siRNA (m) - sc-42238 from Santa Cruz Biotechnology
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SR-3A shRNA Plasmid (m) - sc-42238-SH from Santa Cruz Biotechnology
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SR-3A shRNA (m) Lentiviral Particles - sc-42238-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU053551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33551 from Sigma-Aldrich
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HTR3A siRNA (Mouse) - CRM1965 from Cohesion Biosciences
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HTR3A - MBS8240669 from MyBioSource
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shRNA set against Mouse HTR3A (NM_013561.2) - SHH315953 from Creative biogene
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shRNA set against Mouse Htr3a(NM_013561.2) - SHH135839 from Creative biogene
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HTR3A shRNA Plasmid (Mouse) - CHM1965 from Cohesion Biosciences
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HTR3A miRNA 3'UTR clone - MiUTR1M-05849 from Creative biogene
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