ADAM17

Gene Symbol	ADAM17
Entrez Gene	6868
Alt Symbol	ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase domain 17
Other Description	ADAM metallopeptidase domain 18|TNF-alpha convertase|TNF-alpha converting enzyme|disintegrin and metalloproteinase domain-containing protein 17|snake venom-like protease|tumor necrosis factor, alpha, converting enzyme
Swissprots	P78536 O60226
Accessions	AAX93091 AAX93142 AAY14859 EAX00981 EAX00982 P78536 AK289829 BAF82518 AY422721 BC062687 AAH62687 BC136783 AAI36784 BC146658 AAI46659 BM725368 BQ186514 BX339672 CN258241 GQ402545 ACV30013 U69611 AAB51514 U69612 AAB53014 U86755 AAB51586 U92649 AAC39721 XM_011510375 XP_011508677 XM_011510376 XP_011508678 XM_011510377 XP_011508679 XM_011510378 XP_011508680 NM_003183 NP_003174
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. {ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Top Pathways	Notch signaling pathway, Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TACE (ADAM17) Human ELISA Kit - ab113321 from Abcam Category ELISA Kit Prices $749.00 Sizes 1 x 96 tests Sensitivity < 70 pg/ml Range 78.15 pg/ml - 5000 pg/ml

Human ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F6383 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 0.06 ng/ml Range 78.15-2500 pg/ml

Human ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F188 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 78.15 pg/ml Range 78.15-2500 pg/ml

Rat ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F8499 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.112 ng/ml Range 78.15-2500 pg/ml

Human ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F10739 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 78.15-2500 pg/ml

Human TACE ELISA Kit - RAB0003 from Sigma-Aldrich Category ELISA Kit Prices $608.00 Sizes 1 kt

Human TACE/ADAM17 DuoSet ELISA - DY930 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Human ADAM17 ELISA Kit - abx150545 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

A Disintegrin And Metalloprotease 17 (ADAM17), Human, ELISA Kit - SEB555Hu from ARP American Research Products Category ELISA Kit Prices $545.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), Human, ELISA Kit - E01D0276 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Disintegrin and metalloproteinase domain-containing protein 17, ADAM17, Human, ELISA Kit - E1319h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

TNF a Converting Enzyme, TACE, Human, ELISA Kit - E-EL-H2305 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/ml

TNF a Converting Enzyme, TACE, Rabbit, ELISA Kit - E-EL-RB0834 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

TNF a Converting Enzyme, TACE, Chicken, ELISA Kit - E-EL-Ch0783 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

TNF a Converting Enzyme, TACE, Porcine, ELISA Kit - E-EL-P0588 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

TNF a Converting Enzyme, TACE, Monkey, ELISA Kit - E-EL-MK0368 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ADAM17 (Human) ELISA Kit - KA2145 from Acris Antibodies Category ELISA Kit Prices $780.00 Sizes 1 kit

Human TACE ELISA - ELH-TACE from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 70 pg/ml Range 70 pg/ml - 5000 pg/ml

ADAM metallopeptidase domain 17, ELISA Kit - MBS701544 from MyBioSource Category ELISA Kit Prices $250.00, $435.00, $625.00, $2,595.00, $4,905.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 15.6 pg/ml. Range 62.5 pg/ml -4000 pg/ml.

Human ADAM17 ELISA Kit - DEIA3072 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of TACE is typically less than 70 pg/mL.

Human TACE ELISA Kit - DEIA5787 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of TACE is typically less than 70 pg/mL.

Human TACE(TNF α Converting Enzyme) ELISA Kit - E-EL-H2305 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Disintegrin and metalloproteinase domain containing protein 17 (ADAM17), ELISA Kit - MBS7212595 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Disintegrin and metalloproteinase domain-containing protein 17, ELISA Kit - MBS281226 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), ELISA Kit - MBS7203636 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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