Gene Symbol | STAR |
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Entrez Gene | 6770 |
Alt Symbol | STARD1 |
Species | Human |
Gene Type | protein-coding |
Description | steroidogenic acute regulatory protein |
Other Description | START domain containing 1|START domain-containing protein 1|StAR-related lipid transfer (START) domain containing 1|cholesterol trafficker|mitochondrial steroid acute regulatory protein|steroid acute regulatory protein|steroidogenic acute regulator|steroidogenic acute regulatory protein, mitochondrial |
Swissprots | P49675 Q16396 |
Accessions | AAC50234 ABA25863 ABA25864 ABB51615 AER36553 EAW63334 EAW63335 P49675 AF035277 AAB88174 AK090513 AK315122 BAG37577 AL526126 AV706111 AV706872 AV707696 AV708514 AY532319 AAS57684 BC010550 AAH10550 BX647744 CR456803 CAG33084 CR541850 CAG46648 DQ891806 ABM82732 DQ894990 ABM85916 S79669 AAB35726 U17280 AAC50141 XM_006716392 XP_006716455 NM_000349 NP_000340 NM_001007243 |
Function | Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. |
Subcellular Location | Mitochondrion. |
Tissue Specificity | Expressed in gonads, adrenal cortex and kidney. |
Top Pathways | Ovarian steroidogenesis |
StAR CRISPR/Cas9 KO Plasmid (h) - sc-400961 from Santa Cruz Biotechnology
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StAR HDR Plasmid (h) - sc-400961-HDR from Santa Cruz Biotechnology
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StAR Double Nickase Plasmid (h) - sc-400961-NIC from Santa Cruz Biotechnology
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StAR Double Nickase Plasmid (h2) - sc-400961-NIC-2 from Santa Cruz Biotechnology
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StAR CRISPR Activation Plasmid (h) - sc-400961-ACT from Santa Cruz Biotechnology
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StAR CRISPR Activation Plasmid (h2) - sc-400961-ACT-2 from Santa Cruz Biotechnology
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StAR Lentiviral Activation Particles (h) - sc-400961-LAC from Santa Cruz Biotechnology
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StAR Lentiviral Activation Particles (h2) - sc-400961-LAC-2 from Santa Cruz Biotechnology
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StAR siRNA (h) - sc-44121 from Santa Cruz Biotechnology
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StAR shRNA Plasmid (h) - sc-44121-SH from Santa Cruz Biotechnology
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StAR shRNA (h) Lentiviral Particles - sc-44121-V from Santa Cruz Biotechnology
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StAR RNAi - H00006770-R01V from Novus Biologicals
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StAR RNAi - H00006770-R01 from Novus Biologicals
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MISSION® esiRNA - EHU024811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20698 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20698 from Sigma-Aldrich
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STAR siRNA (Human) - CRH4628 from Cohesion Biosciences
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StAR RNAi - H00006770-R02 from Novus Biologicals
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STAR - MBS8235566 from MyBioSource
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StAR CRISPR/Cas9 KO Plasmid (h2) - sc-400961-KO-2 from Santa Cruz Biotechnology
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StAR HDR Plasmid (h2) - sc-400961-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human STAR (NM_000349.2) - SHH419252 from Creative biogene
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shRNA set against Human STAR(NM_000349.2) - SHL039918 from Creative biogene
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Human STAR siRNA - orb265130 from Biorbyt
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STAR shRNA Plasmid (Human) - CHH4628 from Cohesion Biosciences
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