| Gene Symbol | MMP9 |
|---|---|
| Entrez Gene | 4318 |
| Alt Symbol | CLG4B, GELB, MANDP2, MMP-9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 9 |
| Other Description | macrophage gelatinase|matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)|matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)|matrix metalloproteinase-9|type V collagenase |
| Swissprots | Q9UCL1 Q3LR70 P14780 Q8N725 Q9H4Z1 B2R7V9 Q9UDK2 Q9UCJ9 |
| Accessions | AAD37404 AAM97934 ABA03169 BAA20967 CAC07541 EAW75776 P14780 AK298246 BAH12743 AK301446 BAH13483 AK302530 BAH13736 AK303080 BAH13895 AK311648 AK313137 BAG35956 AK316145 BAH14516 AW468235 BC006093 AAH06093 CN288579 DQ896791 ABM87790 EU176415 ABW03866 HQ874462 AEA49029 J05070 AAA51539 NM_004994 NP_004985 |
| Function | May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000269|PubMed:1480034}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000305}. |
| Tissue Specificity | Produced by normal alveolar macrophages and granulocytes. |
| Top Pathways | Leukocyte transendothelial migration, Bladder cancer, TNF signaling pathway, MicroRNAs in cancer, Estrogen signaling pathway |