BIRC7

Gene Symbol	BIRC7
Entrez Gene	79444
Alt Symbol	KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Species	Human
Gene Type	protein-coding
Description	baculoviral IAP repeat containing 7
Other Description	RING finger protein 50|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|melanoma inhibitor of apoptosis protein
Swissprots	Q96CA5 Q9BQV0 Q9HAP7 Q9H2A8
Accessions	CAC37337 CAC37338 EAW75302 EAW75303 EAW75304 Q96CA5 AF301009 AAG37878 AF311388 AAG33622 AY358835 AAQ89194 AY358836 AAQ89195 AY517497 AAS01729 BC014475 AAH14475 BU737800 DQ893077 ABM84003 DQ896338 ABM87337 NM_022161 NP_071444 NM_139317 NP_647478
Function	Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isof
Subcellular Location	Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Tissue Specificity	Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Livin full length protein - ab87179 from Abcam Category Protein Source E. coli Species Human

Human Livin full length protein - ab59008 from Abcam Category Protein Source E. coli Species Human

Human Livin protein fragment - ab123159 from Abcam Category Protein Source E. coli Species Human

Livin peptide - ab6234 from Abcam Category Peptide

BIRC7 / Livin Antibody Blocking Peptide - LS-E10631 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BIRC7 / Livin Antibody Blocking Peptide - LS-E25224 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BIRC7 / Livin Antibody Blocking Peptide - LS-E8085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BIRC7 / Livin Antibody Blocking Peptide - LS-E29981 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Livin Recombinant Protein - H00079444-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Livin Partial Recombinant Protein - H00079444-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Livin Protein - NBC1-18507 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

Livin Blocking Peptide - NBP1-76711PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Livin Protein - NBP1-99101 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E. coli Species Human

Livin Peptide - P1737 from Novus Biologicals Category Peptide Species Human

BIRC7-Antibody-C-term-Blocking-Peptide - BP6128a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Livin7-ML-IAP - SP2310b from Abgent, a WuXi AppTec company Category Peptide Prices $385.00 Sizes 5 mg

Livin7-ML-IAP - SP2310a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Livin peptide - GTX26234 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Livin blocking peptide - GTX89665-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Livin alpha/KIAP, CF - 1161-LV-100 from R&D Systems Category Protein Source E. coli-derived, Met1-Ser298, with a C-terminal 6-His tag

Recombinant Human Livin beta/ML-IAP, CF - 787-LV-100 from R&D Systems Category Protein Source E. coli-derived, Met1-Ser280, with a C-terminal 6-His tag

BIRC7 Protein (OPPA01727) - OPPA01727 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Livin (His Tag) protein - orb179624 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source E. coli Species Human

Human BIRC7, (1-280 a.a.) protein - orb167982 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human BIRC7 protein - orb80968 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

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