| Gene Symbol |
ARCN1
|
| Entrez Gene |
372
|
| Alt Symbol |
COPD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
archain 1
|
| Other Description |
archain vesicle transport protein 1|coatomer delta subunit|coatomer protein complex, subunit delta|coatomer protein delta-COP|coatomer subunit delta|delta-COP|delta-coat protein
|
| Swissprots |
Q52M80 P48444 E9PEU4 B4E1X2
|
| Accessions |
ACA05943 ACA05944 EAW67397 EAW67398 EAW67399 P48444 AA856562 AK304019 BAG64934 AK312298 BAG35225 AU125652 BC064936 AAH64936 BC080638 BC093636 AAH93636 BC093638 AAH93638 BI560739 BQ018687 BX640860 CAE45922 CR988766 DB216489 X81197 CAA57071 XM_005271542 XP_005271599 NM_001142281 NP_001135753 NM_001655 NP_001646
|
| Function |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed.
|