| Gene Symbol |
BRAP
|
| Entrez Gene |
8315
|
| Alt Symbol |
BRAP2, IMP, RNF52
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BRCA1 associated protein
|
| Other Description |
BRCA1-associated protein|RING finger protein 52|galectin-2-binding protein|impedes mitogenic signal propagation|renal carcinoma antigen NY-REN-63
|
| Swissprots |
O43238 B4DRM1 O75341 Q7Z569 B9EGS8
|
| Accessions |
EAW97972 Q7Z569 AB208878 BAD92115 AF035620 AAC24200 AF035950 AAB88538 AK290379 BAF83068 AK299326 BAG61333 AK308279 AY332222 AAP93638 BC136698 AAI36699 BC136699 AAI36700 BU674276 DB460078 XM_005253944 XP_005254001 XM_011538788 XP_011537090 XM_011538789 XP_011537091 NM_006768 NP_006759
|
| Function |
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9497340}.
|
| Tissue Specificity |
Expressed in breast epithelial cell lines. {ECO:0000269|PubMed:9497340}.
|