BBS2

Gene Symbol BBS2
Entrez Gene 583
Alt Symbol BBS
Species Human
Gene Type protein-coding
Description Bardet-Biedl syndrome 2
Other Description Bardet-Biedl syndrome 2 protein
Swissprots Q96SN9 Q96CM0 Q9BXC9
Accessions EAW82863 EAW82864 Q9BXC9 AB208905 BAD92142 AF342736 AAK28552 AK027635 BAB55252 AK127290 AK289604 BAF82293 AK309068 AL834176 CAD38873 BC014140 AAH14140 BM982214 DA437930 DB316257 DQ892680 ABM83606 DQ895923 ABM86849 XM_005256080 XP_005256137 XM_005256081 XP_005256138 XM_005256082 XP_005256139 XM_011523251 XP_011521553 XR_933378 XR_933379 XR_933380 NM_031885 NP_114091
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity Widely expressed.

BBS2 (A-12) - sc-365355 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BBS2 (A-12): sc-365355. Western blot analysis of BBS2 expression in NTERA-2 cl.D1 whole cell lysate.

BBS2 (C-16) - sc-49381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BBS2 (C-16): sc-49381. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

BBS2 (H-246) - sc-99057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

BBS2 (S-19) - sc-49384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-BBS2 antibody - ab197159 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BBS2 antibody (ab197159) at 1/500 dilutionLane 1 : 293T cell lysateLane 2 : Raji cell lysate

Anti-BBS2 antibody - ab68223 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-BBS2 antibody (ab68223) at 1/500 dilutionLane 1 : BBS2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-BBS2 antibody [EPR13183] - ab181134 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13183
All lanes : Anti-BBS2 antibody [EPR13183] (ab181134) at 1/10000 dilutionLane 1 : NTERA2/D1 cell lysateLane 2 : NCCIT cell lysateLane 3 : MCF-7 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-BBS2 antibody - N-terminal - ab86158 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BBS2 / BBS Antibody (aa315-364) - LS-C135606 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BBS2 antibody LS-C135606 Western blot of COLO205 cell lysate.

Anti-BBS2 / BBS Antibody (aa151-200) - LS-C135607 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BBS2 antibody LS-C135607 Western blot of MCF7 Cell lysate. Antibody concentration 1 ug/ml.

Anti-BBS2 / BBS Antibody - LS-C306507 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

BBS2 Antibody - NBP1-69082 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BBS2 Antibody [NBP1-69082] - Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell.

BBS2 Antibody - NBP1-91695 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: BBS2 Antibody [NBP1-91695] - Staining of human fallopian tube shows strong membranous and cytoplasmic positivity in ciliated cells.

BBS2 Antibody - H00000583-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

BBS2 Polyclonal Antibody - bs-11506R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11506R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11506R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11506R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11506R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, Cy3 Conjugated - bs-11506R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, Cy5 Conjugated - bs-11506R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, Cy5.5 Conjugated - bs-11506R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, Cy7 Conjugated - bs-11506R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, FITC Conjugated - bs-11506R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BBS2 Polyclonal Antibody, Biotin Conjugated - bs-11506R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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