PRKACA

Gene Symbol	PRKACA
Entrez Gene	5566
Alt Symbol	PKACA, PPNAD4
Species	Human
Gene Type	protein-coding
Description	protein kinase, cAMP-dependent, catalytic, alpha
Other Description	PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit
Swissprots	Q32P54 Q9NRH9 Q9H2Y0 Q9NRB4 P17612
Accessions	ABG25918 EAW84397 EAW84398 EAW84399 EAW84400 P17612 AF208004 AAG35720 AF224718 AAF75622 AF239744 AAF76426 AK093803 AK131561 AK290147 BAF82836 AK292284 BAF84973 AK301264 BAH13444 BC039846 AAH39846 BC108259 AAI08260 BU543573 M80335 AAA60094 X07767 CAA30597 NM_001304349 NP_001291278 NM_002730 NP_002721 NM_207518 NP_997401
Function	Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi
Subcellular Location	Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}.
Top Pathways	Calcium signaling pathway, Ovarian steroidogenesis, MAPK signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PKA C-α siRNA II - 6574 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PKA C-α siRNA I - 6406 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections)

PKAα cat CRISPR/Cas9 KO Plasmid (h) - sc-400262 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat HDR Plasmid (h) - sc-400262-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat Double Nickase Plasmid (h) - sc-400262-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat Double Nickase Plasmid (h2) - sc-400262-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat CRISPR Activation Plasmid (h) - sc-400262-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat CRISPR Activation Plasmid (h2) - sc-400262-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat Lentiviral Activation Particles (h) - sc-400262-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat Lentiviral Activation Particles (h2) - sc-400262-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKAα cat siRNA (h) - sc-36240 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKAα cat shRNA Plasmid (h) - sc-36240-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKAα cat shRNA (h) Lentiviral Particles - sc-36240-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU132541 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1790 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1788 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1789 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1576 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1576 from Sigma-Aldrich Category ZFN Kit

PRKACA siRNA (Human) - CRH3738 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKA C alpha RNAi - H00005566-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PKA C alpha RNAi - H00005566-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PRKACA(NM_002730.3) - SHR139560 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PRKACA(NM_207518.1) - SHR139638 from Creative biogene Category siRNA Species Reactivities Human

PRKACA shRNA Plasmid (Human) - CHH3738 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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