HDAC1

Gene Symbol HDAC1
Entrez Gene 404126
Alt Symbol -
Species Bovine
Gene Type protein-coding
Description histone deacetylase 1
Other Description HD1
Swissprots Q32PJ8
Accessions DAA32275 Q32PJ8 AY504948 AAR98734 BC108088 AAI08089 BT030718 ABS45034 XM_005202895 XP_005202952 NM_001037444 NP_001032521
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease

Anti-HDAC1 antibody - ab19845 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
The image shows staining of human tonsil tissue using ab19845. Staining was nuclear and was equally successful using Tris EDTA pH9 or Citrate pH6 for antigen retrieval. Staining was prevalent in almost all cellular compartments of the tonsil.

Anti-HDAC1 antibody - ab33278 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC1 antibody (ab33278) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 3 : Zebrafish Embryo ExtractLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HDAC1 antibody - ab137652 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HDAC1 antibody (ab137652) at 1/1000 dilution + Hela whole cell lysate at 30 µg

Anti-HDAC1 antibody - ab133155 from Abcam

Host Goat
Clonality Polyclonal
Anti-HDAC1 antibody (ab133155) at 0.5 µg/ml ( 1 hour) + HeLa cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-HDAC1 antibody [1.T.9] - ChIP Grade - ab31263 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1.T.9
ab31263 staining HDAC1 in COS7 cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with 0.3% Triton X-100 and blocked with 2% BSA for 1 hour at 25°C. Samples were incubated with primary antibody (1/200 in 2% BSA) for 1 hour at 25°C. A DyLight® 488-conjugated goat anti-mouse IgG polyclonal (1/100) was used as the secondary antibody.See Abreview

Anti-HDAC1 antibody [10E2] (FITC) - ab187946 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 10E2

Anti-HDAC1 antibody [10E2] - C-terminal (HRP) - ab187947 from Abcam

Prices $368.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10E2

Anti-HDAC1 antibody [mAbcam 68436] - Nuclear Loading Control - ab68436 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam 68436
Anti-HDAC1 antibody [mAbcam 68436] - Nuclear Loading Control (ab68436) at 5 µg/ml + IOUD2 Whole Cell Lysate at 20 µgSecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-HDAC1 antibody - C-terminal - ab184651 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HDAC1 antibody - C-terminal (ab184651) at 1 µg/ml + HeLa cell extract

Anti-HDAC1 antibody - C-terminal - ab178918 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HDAC1 antibody - C-terminal (ab178918) at 1 µg/ml + Human esophagus tumour tissue lysate at 10 µg
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