| Gene Symbol |
Egfr
|
| Entrez Gene |
37455
|
| Alt Symbol |
C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DEgfr, Degfr, Der, DmHD-33, Dmel\CG10079, EFG-R, EGF-R, EGFR, EGFr, EGfr, EK2-6, Egf, Egf-r, EgfR, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, Flb, HD-
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
Epidermal growth factor receptor
|
| Other Description |
CG10079-PA|CG10079-PB|DER-Ellipse|EGF-receptor|EGFR|Egf receptor|Egfr-PA|Egfr-PB|drosophila epidermal growth factor receptor homologue|ellipse|ellipse torpedo|epidermal growth factor receptor|faint little ball|morphological defects 1|torpedo|torpedo/DER
|
| Swissprots |
Q9W2G0 O18370 P04412 P81868 O61601
|
| Accessions |
AAF46732 AAM70919 Q8MLW0 NM_057410 NP_476758 NM_057411 NP_476759
|
| Function |
Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf- MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair. {ECO:0000269|PubMed:22140578}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed in embryos. In larvae, uniform expression is seen in wing disks, genital disk, anlagen of testis and ovary, and brain cortex. In eye-antenna disk, highest expression is anterior to morphogenetic furrow, levels remain high in photoreceptor precursor cells. This pattern is reversed in posterior eye disk. In adults expression is high in brain cortex and thoracic and abdominal ganglia. {ECO:0000269|PubMed:9882502}.
|
| Top Pathways |
Endocytosis, Dorso-ventral axis formation, MAPK signaling pathway - fly
|