| Gene Symbol |
RAB11A
|
| Entrez Gene |
100009072
|
| Alt Symbol |
RAB11
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
RAB11A, member RAS oncogene family
|
| Other Description |
rab-11|ras-related protein Rab-11A|tubulovesicle-associated protein
|
| Swissprots |
P62493
|
| Accessions |
P62493 DN889586 L13927 L19260 AAA31491 NM_001082251 NP_001075720
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (By similarity). Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
A prominent expression is seen in gastric parietal cells. {ECO:0000269|PubMed:8074219}.
|
| Top Pathways |
Endocytosis, Vasopressin-regulated water reabsorption, Pancreatic secretion, Endocrine and other factor-regulated calcium reabsorption
|