| Gene Symbol |
Cyp46a1
|
| Entrez Gene |
13116
|
| Alt Symbol |
Cyp46
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 46, subfamily a, polypeptide 1
|
| Other Description |
CH24H|cholesterol 24-hydroxylase|cholestrol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, 46 (cholesterol 24-hydroxylase)|cytochrome P450, 46a1 (cholesterol 24-hydroxylase)
|
| Swissprots |
Q9WVK8
|
| Accessions |
EDL18715 EDL18716 Q9WVK8 AF094479 AAD41243 AK140740 BAE24462 BC018307 AAH18307 XM_006515456 XP_006515519 XR_381477 NM_010010 NP_034140
|
| Function |
Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in high level in brain (cerebral cortex, hippocampus, dentate gyrus and thalamus) and in lower levels in testis and liver. Brain's expression increased linearly with age.
|
| Top Pathways |
Primary bile acid biosynthesis
|
![Anti-CYP46A1 antibody [N1C2] used in Western blot. GTX105183](http://www.bioprodhub.com/system/product_images/ab_products/13/sub_1/17666_GTX105183_39925_WB_M_Brain.jpg)
