Gene Symbol | SLC26A3 |
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Entrez Gene | 1811 |
Alt Symbol | CLD, DRA |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 26 (anion exchanger), member 3 |
Other Description | chloride anion exchanger|down-regulated in adenoma protein|solute carrier family 26, member 3 |
Swissprots | P40879 |
Accessions | AAB88772 EAW83418 EAW83419 EAW83420 P40879 AK300651 BAG62339 BC025671 AAH25671 BP262081 BX640837 CAE45910 DQ891550 ABM82476 EU176616 ABW03417 L02785 AAA58443 XM_011515867 XP_011514169 NM_000111 NP_000102 |
Function | Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:22159084}; Multi-pass membrane protein {ECO:0000269|PubMed:22159084}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}. |
Top Pathways | Pancreatic secretion, Mineral absorption |
SLC26A3 CRISPR/Cas9 KO Plasmid (h) - sc-403891 from Santa Cruz Biotechnology
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SLC26A3 HDR Plasmid (h) - sc-403891-HDR from Santa Cruz Biotechnology
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SLC26A3 Double Nickase Plasmid (h) - sc-403891-NIC from Santa Cruz Biotechnology
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SLC26A3 Double Nickase Plasmid (h2) - sc-403891-NIC-2 from Santa Cruz Biotechnology
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SLC26A3 CRISPR Activation Plasmid (h) - sc-403891-ACT from Santa Cruz Biotechnology
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SLC26A3 CRISPR Activation Plasmid (h2) - sc-403891-ACT-2 from Santa Cruz Biotechnology
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SLC26A3 Lentiviral Activation Particles (h) - sc-403891-LAC from Santa Cruz Biotechnology
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SLC26A3 Lentiviral Activation Particles (h2) - sc-403891-LAC-2 from Santa Cruz Biotechnology
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SLC26A3 siRNA (h) - sc-45543 from Santa Cruz Biotechnology
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SLC26A3 shRNA Plasmid (h) - sc-45543-SH from Santa Cruz Biotechnology
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SLC26A3 shRNA (h) Lentiviral Particles - sc-45543-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19524 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19524 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03173 from Sigma-Aldrich
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SLC26A3 siRNA (Human) - CRH1263 from Cohesion Biosciences
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SLC26A3 RNAi - H00001811-R01 from Novus Biologicals
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SLC26A3 - MBS8230407 from MyBioSource
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shRNA set against Human SLC26A3 (NM_000111.2) - SHH409956 from Creative biogene
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Human SLC26A3 siRNA - orb261765 from Biorbyt
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SLC26A3 shRNA Plasmid (Human) - CHH1263 from Cohesion Biosciences
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SLC26A3 miRNA 3'UTR clone - MiUTR4H-TG12471 from Creative biogene
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