SUV39H2

Gene Symbol SUV39H2
Entrez Gene 79723
Alt Symbol KMT1B
Species Human
Gene Type protein-coding
Description suppressor of variegation 3-9 homolog 2 (Drosophila)
Other Description H3-K9-HMTase 2|histone H3-K9 methyltransferase 2|histone-lysine N-methyltransferase SUV39H2|lysine N-methyltransferase 1B|su(var)3-9 homolog 2
Swissprots D3DRT4 Q5JSS4 Q8ND06 Q6I9Y3 Q5JSS5 Q9H5I1
Accessions EAW86253 EAW86254 EAW86255 EAW86256 EAW86257 Q9H5I1 AK027067 BAB15645 AK222565 AK225369 AL834488 CAD39146 BC007754 AAH07754 BC029360 AAH29360 BU928392 CR457372 CAG33653 DB040298 DQ896015 ABM87014 EU176399 ABW03850 XM_006717503 XP_006717566 XM_011519661 XP_011517963 XM_011519662 XP_011517964 NM_001193424 NP_001180353 NM_001193425 NP_001180354 NM_001193426 NP_001180355 NM_001193427 NP_001180356 NM_024670 NP_078946 NR_034181
Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chrom
Subcellular Location Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
Top Pathways Lysine degradation

suppressor of variegation 3-9 homolog 2 (Drosophila) , ELISA Kit - MBS9316628 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SUV39H2 ELISA Kit - E036979 from Biobool

Category ELISA Kit

anti-KMT1B / SUV39H2 antibody - ARG63373 from Arigo Biolaboratories

Category ELISA Kit

anti-KMT1B / SUV39H2 antibody - ARG54750 from Arigo Biolaboratories

Category ELISA Kit

anti-KMT1B / SUV39H2 antibody - ARG54796 from Arigo Biolaboratories

Category ELISA Kit

Histone-Lysine N-Methyltransferase SUV39H2 (SUV39H2), ELISA Kit - MBS9903053 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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