Gene Symbol | Il1a |
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Entrez Gene | 16175 |
Alt Symbol | Il-1a |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 1 alpha |
Other Description | IL-1 alpha|interleukin-1 alpha |
Swissprots | P01582 |
Accessions | AAC28999 AAX90603 EDL28236 EDL28237 P01582 AK156449 BAE33715 BC003727 AAH03727 M14639 AAA40058 X01450 CAA25682 XM_006498793 XP_006498856 XM_006498794 XP_006498857 NM_010554 NP_034684 |
Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
Top Pathways | Apoptosis, Inflammatory bowel disease (IBD), Non-alcoholic fatty liver disease (NAFLD), Hematopoietic cell lineage, Graft-versus-host disease |
IL-1α CRISPR/Cas9 KO Plasmid (m) - sc-421096 from Santa Cruz Biotechnology
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IL-1α HDR Plasmid (m) - sc-421096-HDR from Santa Cruz Biotechnology
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IL-1α Double Nickase Plasmid (m) - sc-421096-NIC from Santa Cruz Biotechnology
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IL-1α Double Nickase Plasmid (m2) - sc-421096-NIC-2 from Santa Cruz Biotechnology
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IL-1α CRISPR Activation Plasmid (m) - sc-421096-ACT from Santa Cruz Biotechnology
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IL-1α CRISPR Activation Plasmid (m2) - sc-421096-ACT-2 from Santa Cruz Biotechnology
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IL-1α Lentiviral Activation Particles (m) - sc-421096-LAC from Santa Cruz Biotechnology
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IL-1α Lentiviral Activation Particles (m2) - sc-421096-LAC-2 from Santa Cruz Biotechnology
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IL-1α siRNA (m) - sc-39614 from Santa Cruz Biotechnology
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IL-1α shRNA Plasmid (m) - sc-39614-SH from Santa Cruz Biotechnology
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IL-1α shRNA (m) Lentiviral Particles - sc-39614-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33758 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33758 from Sigma-Aldrich
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IL1A siRNA (Mouse) - CRM2049 from Cohesion Biosciences
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IL1A - MBS8200312 from MyBioSource
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shRNA set against Mouse IL1A (NM_010554.4) - SHH318481 from Creative biogene
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shRNA set against Mouse Il1a(NM_010554.4) - SHL172146 from Creative biogene
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IL1A shRNA Plasmid (Mouse) - CHM2049 from Cohesion Biosciences
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IL1A miRNA 3'UTR clone - MiUTR1M-05988 from Creative biogene
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