CERS3

Gene Symbol CERS3
Entrez Gene 204219
Alt Symbol ARCI9, LASS3
Species Human
Gene Type protein-coding
Description ceramide synthase 3
Other Description LAG1 homolog, ceramide synthase 3|LAG1 longevity assurance homolog 3|dihydroceramide synthase 3
Swissprots Q8IU89 Q8NE64 Q8NEN6
Accessions EAX02267 EAX02268 EAX02269 Q8IU89 AK307191 BC027616 BC028703 AAH28703 BC034500 AAH34500 BC034970 AAH34970 DQ890899 ABM81825 EU176496 ABW03297 HY022150 XM_011521355 XP_011519657 XM_011521356 XP_011519658 XM_011521357 XP_011519659 XM_011521358 XP_011519660 NM_001290341 NP_001277270 NM_001290342 NP_001277271 NM_001290343 NP_001277272 NM_178842 NP_849164
Function Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. {ECO:0000250, ECO:0000269|PubMed:23754960}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level). {ECO:0000269|PubMed:23754960}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

LASS3 (T-17) - sc-55962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LASS3 (T-17): sc-55962. Western blot analysis of LASS3 expression in Jurkat nuclear extract.

LASS3 (O-25) - sc-133725 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
LASS3 (O-25): sc-133725. Western blot analysis of LASS3 expression in Jurkat nuclear extract.

Anti-LASS3 antibody - ab28637 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LASS3 antibody (ab28637) at 0.5 µg/ml + Foetal liver lysate 10ug.SecondaryHRP conjugated anti-Rabbit IgG 1: 50,000 - 100,000

Anti-LASS3 antibody - ab79717 from Abcam

Host Goat
Clonality Polyclonal

Anti-LASS3 antibody - ab77415 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-LASS3 antibody (ab77415) at 0.2 µg/ml + Rat testis lysate in RIPA buffer at 35 µg

Anti-LASS3 antibody - ab169259 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-LASS3 antibody (ab169259) at 1 µg/mlLane 1 : LASS3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-LASS3 Antibody (aa54-103) - LS-C29860 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal Liver Lysate

Anti-LASS3 Antibody (aa370-383) - LS-C87345 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.2 ug/ml) staining of Rat Testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Anti-LASS3 Antibody - LS-C140581 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Western blot of LAG1 longevity assurance homolog 3 (LS-C140581) at 2.5 ug/ml on human testis lysate 14 ug/lane. Lane A] antibody alone, Lane B] antibody blocked with 40 ug blocking peptide. Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at dilution used 1:3.5K. Exposure for 3 minutes

LASS3 Antibody - NBP1-84536 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LASS3 Antibody - NBP1-84535 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LASS3 Antibody [NBP1-84535] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-314

LASS3 Antibody - NBP1-02313 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: LASS3 Antibody [NBP1-02313] - (0.2ug/ml) staining of Rat Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

LASS3 Antibody (6C12) - H00204219-M02-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C12

LASS3 Antibody - H00204219-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

LASS3 Antibody - H00204219-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Monoclonal Anti-LASS3 antibody produced in mouse - SAB1412935 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C12
<B>Immunoblotting</B><BR/>Anti-LASS3:<B>Cat. No. SAB1412935</B>: Antibody concentration: 1–5 μg/mL. Immunofluorescence band of ~47 kDa using MCF-7 lysate.

Anti-CERS3 antibody produced in rabbit - HPA024356 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LASS3: <B>Cat. No. HPA024356</B>: Immunohistochemical staining of human bronchus shows strong cytoplasmic positivity in respiratory epithelial cells.

Anti-CERS3 antibody produced in rabbit - HPA006092 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LASS3: <B>Cat. No. HPA006092</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placental tissue showing nuclear as well as some cytoplasmic staining of decidual and trophoblastic cells.

Anti-LASS3/CERS3 antibody produced in goat - SAB2500585 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LASS3 / CerS3: <B>Cat. No. SAB2500585</B>: (0.2 μg/mL) staining of Rat Testis lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-LASS3 antibody produced in rabbit - AV31648 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal liver (<B>Cat. No. AV31648</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type fetal liver

LASS3 antibody - N-terminal region (ARP31648_P050) - ARP31648_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LASS3--CerS3-Antibody - AF1615a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1615a (0.2 µg/ml) staining of Rat Testis lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Anti-LASS3 / CerS3 Antibody (OAEB01886) - OAEB01886 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti -LASS3 (LAG1 Longevity Assurance Homolog 3) - L1379-08 from USBiological Life Science

Host Goat
Clonality Polyclonal
Search more