Gene Symbol | DNAH2 |
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Entrez Gene | 146754 |
Alt Symbol | DNAHC2, DNHD3 |
Species | Human |
Gene Type | protein-coding |
Description | dynein, axonemal, heavy chain 2 |
Other Description | axonemal beta dynein heavy chain 2|ciliary dynein heavy chain 2|dynein heavy chain 2, axonemal|dynein heavy chain domain-containing protein 3|dynein, axonemal, heavy polypeptide 2 |
Swissprots | O15434 B5MDX5 Q6ZR42 Q9P225 Q6PIH3 A8K992 |
Accessions | AAB82760 CCQ43655 EAW90129 EAW90130 EAW90131 Q9P225 AB040936 BAA96027 AK128517 AK292607 BAF85296 BC034225 AAH34225 BQ638815 BX648163 XM_011523663 XP_011521965 XM_011523664 XP_011521966 XM_011523665 XP_011521967 XM_011523666 XP_011521968 XM_011523667 XP_011521969 XM_011523668 XP_011521970 XM_011523669 XP_011521971 XM_011523670 XP_011521972 NM_001303270 NP_001290199 NM_020877 NP_065928 |
Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. |
Tissue Specificity | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. {ECO:0000269|PubMed:9256245}. |
Top Pathways | Huntington's disease |
DNAH2 CRISPR/Cas9 KO Plasmid (h) - sc-414589 from Santa Cruz Biotechnology
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DNAH2 HDR Plasmid (h) - sc-414589-HDR from Santa Cruz Biotechnology
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DNAH2 Double Nickase Plasmid (h) - sc-414589-NIC from Santa Cruz Biotechnology
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DNAH2 Double Nickase Plasmid (h2) - sc-414589-NIC-2 from Santa Cruz Biotechnology
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DNAH2 CRISPR Activation Plasmid (h) - sc-414589-ACT from Santa Cruz Biotechnology
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DNAH2 CRISPR Activation Plasmid (h2) - sc-414589-ACT-2 from Santa Cruz Biotechnology
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DNAH2 Lentiviral Activation Particles (h) - sc-414589-LAC from Santa Cruz Biotechnology
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DNAH2 Lentiviral Activation Particles (h2) - sc-414589-LAC-2 from Santa Cruz Biotechnology
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DNAH2 siRNA (h) - sc-93709 from Santa Cruz Biotechnology
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DNAH2 shRNA Plasmid (h) - sc-93709-SH from Santa Cruz Biotechnology
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DNAH2 shRNA (h) Lentiviral Particles - sc-93709-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7332 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7332 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00433 from Sigma-Aldrich
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DNAH2 siRNA (Human) - CRJ5488 from Cohesion Biosciences
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DNAH2 - MBS8213227 from MyBioSource
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shRNA set against Human DNAH2 (NM_020877.2) - SHH279101 from Creative biogene
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Human DNAH2 siRNA - orb275989 from Biorbyt
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DNAH2 shRNA Plasmid (Human) - CHJ5488 from Cohesion Biosciences
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DNAH2 miRNA 3'UTR clone - MiUTR1H-02897 from Creative biogene
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