| Gene Symbol |
HTRA2
|
| Entrez Gene |
27429
|
| Alt Symbol |
OMI, PARK13, PRSS25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HtrA serine peptidase 2
|
| Other Description |
HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI
|
| Swissprots |
O43464 Q9HBZ4 Q9P0Y4 Q9P0Y3
|
| Accessions |
ABU25433 EAW99617 EAW99618 EAW99619 EAW99620 EAW99621 O43464 AF020760 AAB94569 AF141305 AAF66596 AF141306 AAF66597 AF141307 AAF66598 AF184911 AAG13126 AK225932 AK291977 BAF84666 AK310163 BC000096 AAH00096 BF939362 DQ891822 ABM82748 DQ895009 ABM85935 EU176308 ABW03759 XM_005264266 XP_005264323 NM_013247 NP_037379 NM_145074 NP_659540
|
| Function |
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
|
| Subcellular Location |
Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
|
| Tissue Specificity |
Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
|