| Gene Symbol | MAPK6 |
|---|---|
| Entrez Gene | 5597 |
| Alt Symbol | ERK3, HsT17250, PRKM6, p97MAPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 6 |
| Other Description | ERK-3|MAP kinase 6|MAP kinase isoform p97|MAPK 6|extracellular signal-regulated kinase 3|extracellular signal-regulated kinase, p97|p97-MAPK|protein kinase, mitogen-activated 5|protein kinase, mitogen-activated 6 |
| Swissprots | Q16659 B5BU65 Q8IYN8 Q68DH4 B2R945 |
| Accessions | EAW77434 Q16659 AB451301 BAG70115 AF420474 AAL17605 AK313633 BAG36392 BC035492 AAH35492 CR749401 CAH18246 DA109756 DQ891618 ABM82544 DQ894810 ABM85736 L77964 AAA98769 X80692 CAA56709 XM_005254536 XP_005254593 XM_005254537 XP_005254594 XM_005254538 XP_005254595 XM_005254539 XP_005254596 XM_011521782 XP_011520084 NM_002748 NP_002739 |
| Function | Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}. |
| Tissue Specificity | Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
Mouse/Human/Rat Phospho-MAPK6 / ERK3 (Ser189) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1357 from LifeSpan Bioscience
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Mouse/Human/Rat MAPK6 / ERK3 ELISA Kit (Cell-Based ELISA) - LS-F1974 from LifeSpan Bioscience
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Extracellular Signal Regulated Kinase 3, ERK3, Human, ELISA Kit - E-EL-H2088 from ARP American Research Products
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Extracellular Signal Regulated Kinase 3, ERK3, Rabbit, ELISA Kit - E-EL-RB2073 from ARP American Research Products
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Extracellular Signal Regulated Kinase 3, ERK3, Chicken, ELISA Kit - E-EL-Ch2106 from ARP American Research Products
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Extracellular Signal Regulated Kinase 3, ERK3, Porcine, ELISA Kit - E-EL-P0054 from ARP American Research Products
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Extracellular Signal Regulated Kinase 3, ERK3, Guinea Pig, ELISA Kit - E-EL-GP0296 from ARP American Research Products
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Extracellular Signal Regulated Kinase 3, ERK3, Monkey, ELISA Kit - E-EL-MK0229 from ARP American Research Products
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MAPK6 (Human) IP-WB Antibody Pair - H00005597-PW1 from Acris Antibodies
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ERK3 Colorimetric Cell-Based ELISA Kit - CB5247 from Assay Biotechnology
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ERK3 (Phospho-Ser189) Colorimetric Cell-Based ELISA Kit - CBP1369 from Assay Biotechnology
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Human ERK3(Extracellular Signal Regulated Kinase 3) ELISA Kit - E-EL-H2088 from Elabscience
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mitogen-activated protein kinase 6, ELISA Kit - MBS9341965 from MyBioSource
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Human ERK2(Extracellular Signal Regulated Kinase 2) ELISA Kit - E-EL-H2088 from Iwai North America Inc.
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ERK3 ELISA Kit - DEIA-XYA615 from Creative Diagnostics
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ERK3 (Phospho-Ser189) ELISA Kit - DEIA-XYA616 from Creative Diagnostics
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Human ERK3 ELISA Kit - E013549 from Biobool
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Human MAPK6 ELISA Kit - E024730 from Biobool
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Human Mitogen-activated protein kinase 12 (MAPK12) ELISA Kit - AE34321HU from ARP American Research Products
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Human MAPK6 / ERK3 ELISA Kit (Sandwich ELISA) - LS-F38028 from LifeSpan Bioscience
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ERK3 Colorimetric Cell-Based ELISA Kit - EKA50209 from Biomatik
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