Gene Symbol | Pla2g4a |
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Entrez Gene | 18783 |
Alt Symbol | Pla2g4, cPLA2, cPLA2-alpha, cPLA2alpha |
Species | Mouse |
Gene Type | protein-coding |
Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
Other Description | Cytosolic phospholipase A2 (CPLA2)|Type IV PLA2|cytosolic PLA2|cytosolic phospholipase A2|phospholipase A2 group IVA|phospholipase A2, group 4 |
Swissprots | P47713 |
Accessions | EDL39489 P47713 AK004701 BAB23486 AK144750 BAE26047 AK172121 BC003816 AAH03816 BQ033204 M72394 AAB00796 XM_006529252 XP_006529315 NM_001305632 NP_001292561 NM_008869 NP_032895 |
Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
Subcellular Location | Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway |
cPLA 2 CRISPR/Cas9 KO Plasmid (m) - sc-422284 from Santa Cruz Biotechnology
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cPLA 2 HDR Plasmid (m) - sc-422284-HDR from Santa Cruz Biotechnology
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cPLA 2 Double Nickase Plasmid (m) - sc-422284-NIC from Santa Cruz Biotechnology
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cPLA 2 Double Nickase Plasmid (m2) - sc-422284-NIC-2 from Santa Cruz Biotechnology
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cPLA 2 CRISPR Activation Plasmid (m) - sc-422284-ACT from Santa Cruz Biotechnology
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cPLA 2 CRISPR Activation Plasmid (m2) - sc-422284-ACT-2 from Santa Cruz Biotechnology
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cPLA 2 Lentiviral Activation Particles (m) - sc-422284-LAC from Santa Cruz Biotechnology
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cPLA 2 Lentiviral Activation Particles (m2) - sc-422284-LAC-2 from Santa Cruz Biotechnology
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cPLA 2 siRNA (m) - sc-35098 from Santa Cruz Biotechnology
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cPLA 2 shRNA Plasmid (m) - sc-35098-SH from Santa Cruz Biotechnology
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cPLA 2 shRNA (m) Lentiviral Particles - sc-35098-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU060371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38824 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38824 from Sigma-Aldrich
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PLA2G4A siRNA (Mouse) - CRM3106 from Cohesion Biosciences
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shRNA set against Mouse Pla2g4a (NM_008869.3) - SHH376812 from Creative biogene
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shRNA set against Mouse Pla2g4a(NM_008869.3) - SHR118974 from Creative biogene
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Mouse PLA2G4A siRNA - orb282582 from Biorbyt
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PLA2G4A shRNA Plasmid (Mouse) - CHM3106 from Cohesion Biosciences
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PLA2G4A miRNA 3'UTR clone - MiUTR1M-09284 from Creative biogene
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