SCNN1B

Gene Symbol SCNN1B
Entrez Gene 6338
Alt Symbol BESC1, ENaCb, ENaCbeta, SCNEB
Species Human
Gene Type protein-coding
Description sodium channel, non voltage gated 1 beta subunit
Other Description amiloride-sensitive sodium channel subunit beta|amiloride-sensitive sodium channel subunit beta 1|beta-ENaC|beta-NaCH|epithelial Na(+) channel subunit beta|epithelial sodium channel beta-2 subunit|epithelial sodium channel beta-3 subunit|nasal epithelial sodium channel beta subunit|nonvoltage-gated sodium channel 1 subunit beta|sodium channel, non-voltage-gated 1, beta subunit|sodium channel, nonvoltage-gated 1, beta
Swissprots Q96KG2 Q9UMU5 O60891 C5HTZ2 Q9UJ32 P51168
Accessions AAA67036 AAL48196 AAL48197 ACS13723 ACS13724 CAA06508 EAW55833 EAW55834 P51168 AF260226 AAK49394 AK313192 BAG36009 AU105979 BC036352 AAH36352 DQ402523 ABD72219 EU831785 ACE87303 EU831863 ACE86622 HQ257906 ADR82661 L36593 AAA75459 X87159 CAA60632 XM_011545913 XP_011544215 XM_011545914 XP_011544216 NM_000336 NP_000327
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:24124190}. Note=Apical membrane of epithelial cells.
Tissue Specificity Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}.
Top Pathways Taste transduction, Aldosterone-regulated sodium reabsorption

SCNN1B-Over-expression-Lysate - LY15603a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SCNN1B (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SCNN1B gene‘

SCNN1B 293 Cell Lysate - 410264 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

epithelial Sodium Channel beta Overexpression Lysate (Native) - NBL1-15746 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: epithelial Sodium Channel beta Overexpression Lysate (Adult Normal) [NBL1-15746] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for epithelial Sodium Channel beta.

βENaC (h3): 293T Lysate - sc-177183 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

SCNN1B Over-expression Lysate Product - GWB-CD269A from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

epithelial Sodium Channel beta Overexpression Lysate (Denatured) - H00006338-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human SCNN1B Knockdown Stable Cell Line - CSC-DC013878 from Creative biogene

Category Cell Line
Species Human
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