| Gene Symbol |
COX1
|
| Entrez Gene |
4512
|
| Alt Symbol |
COI, MTCO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome c oxidase subunit I
|
| Other Description |
-
|
| Swissprots |
Q34770 P00395
|
| Accessions |
AAB58945 YP_003024028
|
| Function |
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
|
| Subcellular Location |
Mitochondrion inner membrane; Multi-pass membrane protein.
|
| Top Pathways |
Alzheimer's disease, Huntington's disease, Cardiac muscle contraction, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation
|