| Gene Symbol |
RHOH
|
| Entrez Gene |
399
|
| Alt Symbol |
ARHH, TTF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras homolog family member H
|
| Other Description |
GTP-binding protein TTF|TTF, translocation three four|ras homolog gene family, member H|rho-related GTP-binding protein RhoH
|
| Swissprots |
Q15669
|
| Accessions |
CAH05283 CAH05284 EAW92960 EAW92961 EAW92962 Q15669 AA767445 AF498975 AAM21122 AI865435 AK097117 AK313744 BAG36484 AW402442 AY673952 AY673953 AY673954 AY673955 AY673956 BC014261 AAH14261 BG025818 BI818548 BI908453 BM457874 BU934664 BX413967 CA447396 CD703012 CR450349 CAG29345 DA383563 DA815617 DA906265 DA950405 DA951252 DB115332 DB119883 DQ892629 ABM83555 DQ895867 ABM86793 Z35227 CAA84538 XM_011513692 XP_011511994 NM_001278359 NP_001265288 NM_001278360 NP_001265289 NM_001278361 NP_001265290 NM_001278362 NP_001265291 NM_001278363 NP_001265292 NM_001278364 NP_001265293 NM_001278365 NP_001265294 NM_001278366 NP_001265295 NM_001278367 NP_001265296 NM_001278368 NP_001265297 NM_001278369 NP_001265298 NM_004310 NP_004301
|
| Function |
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.
|
| Tissue Specificity |
Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis. {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}.
|
| Top Pathways |
Leukocyte transendothelial migration
|